{"id":"W2774629613","doi":"10.12688/mniopenres.12766.1","title":"A lentiviral system for efficient knockdown of proteins in neuronal cultures","year":2017,"lang":"en","type":"article","venue":"MNI Open Research","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Neurological Institute and Hospital","funders":"National Institute of Neurological Disorders and Stroke; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Gene knockdown; Cell biology; Computational biology; Biology; Cell culture; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008619656,0.00007256022,0.0001313227,0.00005211106,0.0002125148,0.0001595179,0.001100345,0.00007796256,0.000008955118],"category_scores_gemma":[0.000199921,0.00005949702,0.00005611248,0.00003625913,0.0001286422,0.00000570366,0.0007929229,0.0001042354,0.00001119442],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001650486,"about_ca_system_score_gemma":0.0001226862,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006101773,"about_ca_topic_score_gemma":0.0003224845,"domain_scores_codex":[0.9989803,0.00009922637,0.000157931,0.0002952099,0.0001933214,0.0002739881],"domain_scores_gemma":[0.9991341,0.00001242276,0.00006218151,0.0005265435,0.0002250796,0.00003973248],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007137895,0.0001742961,0.004200598,0.000133619,0.00002635603,0.000005835234,0.00009170243,0.00007099576,0.9871714,0.0006348377,0.00435031,0.002426266],"study_design_scores_gemma":[0.001124946,0.0008944951,0.0181918,0.0001360745,0.00000298044,0.000002860255,0.000338889,0.000423415,0.9703694,0.00004004663,0.008359353,0.00011572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9890126,0.0001041019,0.00008671035,0.0001909095,0.00006811621,0.001124074,0.00003982523,0.000001541526,0.009372095],"genre_scores_gemma":[0.9966247,0.00001402938,0.000155644,0.000009076021,0.0000767158,0.0002708046,0.00002240616,0.000009086475,0.002817517],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01680197,"threshold_uncertainty_score":0.2426218,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1010003727482137,"score_gpt":0.4235363448138109,"score_spread":0.3225359720655971,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}