{"id":"W2774750904","doi":"10.1093/bioinformatics/btx769","title":"Model-based design of bistable cell factories for metabolic engineering","year":2017,"lang":"en","type":"article","venue":"Bioinformatics","topic":"Microbial Metabolic Engineering and Bioproduction","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Max Planck Institute for Dynamics of Complex Technical Systems Magdeburg; Ontario Ministry of Research and Innovation; Natural Sciences and Engineering Research Council of Canada","keywords":"Bistability; Metabolic engineering; Computer science; Biology; Materials science; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001329854,0.0001126327,0.0001424244,0.00003728026,0.0000893844,0.00003527219,0.0001922198,0.00008641133,9.974747e-7],"category_scores_gemma":[0.0001521906,0.0001023684,0.00006479031,0.00002138478,0.00003030869,0.00001061726,0.00003223678,0.00003138309,0.000001085092],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000003678669,"about_ca_system_score_gemma":0.00005691434,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004358202,"about_ca_topic_score_gemma":4.87794e-7,"domain_scores_codex":[0.9994983,0.000003014972,0.0001979707,0.00008793928,0.00005816405,0.0001546229],"domain_scores_gemma":[0.9992971,0.000003433627,0.0001489501,0.0004241637,0.00009045722,0.00003592268],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002499903,0.00001681523,0.00002229024,0.0001825582,0.00001569389,2.018996e-8,0.00003583554,0.125462,0.8730882,0.0001041388,0.0004790655,0.0005684388],"study_design_scores_gemma":[0.0002886437,0.00005142754,0.00004726012,0.000008376563,0.00001988418,4.722147e-7,0.000007541682,0.2389266,0.7460372,0.000005623412,0.01449933,0.0001077056],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.05897671,0.0002907148,0.9400343,0.00001605071,0.0002718533,0.0002270321,0.00006342532,0.00001576869,0.0001040908],"genre_scores_gemma":[0.7784356,0.0000737493,0.2210299,0.00001283158,0.0001164326,0.0000151895,0.00004175822,0.00001460983,0.0002599186],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.7194589,"threshold_uncertainty_score":0.4174464,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02065703111434475,"score_gpt":0.2298429131124561,"score_spread":0.2091858819981114,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}