{"id":"W2774852405","doi":"10.21037/biotarget.2017.12.01","title":"Vacuolar H+-ATPases (V-ATPases) as therapeutic targets: a brief review and recent developments","year":2017,"lang":"en","type":"review","venue":"Biotarget","topic":"ATP Synthase and ATPases Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Dental and Craniofacial Research; National Institute of Arthritis and Musculoskeletal and Skin Diseases; University of California, San Francisco; University of Toronto","keywords":"ATPase; Enoxacin; V-ATPase; Bafilomycin; Biology; Cell biology; Endosome; Chemistry; Biochemistry; Enzyme; Intracellular","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004930931,0.00084578,0.001276629,0.001832781,0.0002874695,0.001099893,0.0007726405,0.001418148,0.003987371],"category_scores_gemma":[0.0005009894,0.0003054797,0.0006861208,0.001580415,0.0002920637,0.001617643,0.0005712506,0.001715154,0.001959721],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005797357,"about_ca_system_score_gemma":0.00074681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005818104,"about_ca_topic_score_gemma":0.0009836007,"domain_scores_codex":[0.9998267,0.00002738989,0.00002709931,0.00003659511,0.00005356342,0.00002869582],"domain_scores_gemma":[0.9997805,0.0000945053,0.00003628119,0.000006249949,0.00005419592,0.00002831393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002836607,0.0002139412,0.0003772102,0.02614662,0.0001401346,0.0006550747,0.0001539699,0.000580318,0.009660639,0.005743163,0.05627769,0.8997676],"study_design_scores_gemma":[0.00002655924,0.0003191375,0.0006401434,0.001770594,0.0001744287,0.001735006,0.00008318866,0.000178347,0.001627382,0.001390021,0.9920251,0.00003011785],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003249108,0.9976052,0.0002626755,0.0004457755,0.0003746809,0.000009184493,0.00003059212,0.00001791398,0.000929079],"genre_scores_gemma":[0.001160029,0.9965475,0.0004127957,0.0004548366,0.0005460835,0.00001553713,0.00008672416,0.000003764508,0.0007726954],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003987371,"threshold_uncertainty_score":0.0133391,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1043091026067945,"score_gpt":0.4222635770210507,"score_spread":0.3179544744142561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}