{"id":"W2775144572","doi":"10.1136/thoraxjnl-2017-210074","title":"Lung tissue gene-expression signature for the ageing lung in COPD","year":2017,"lang":"en","type":"article","venue":"Thorax","topic":"Chronic Obstructive Pulmonary Disease (COPD) Research","field":"Medicine","cited_by":62,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut universitaire de cardiologie et de pneumologie de Québec; Université Laval; St. Paul's Hospital; University of British Columbia","funders":"Universitair Medisch Centrum Groningen","keywords":"COPD; Ageing; Lung; Medicine; Gene expression profiling; Gene expression; Transcriptome; Gene; Gene signature; Pathology; Immunology; Biology; Genetics; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004480446,0.0001748006,0.0002645354,0.00008326826,0.0005126764,0.00008623064,0.0004351811,0.0001470722,0.0003920644],"category_scores_gemma":[0.0003835276,0.0001210583,0.0000951348,0.000085593,0.0001777484,0.0001740035,0.0002629995,0.0004512544,0.0000268098],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002702628,"about_ca_system_score_gemma":0.0001908754,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000111944,"about_ca_topic_score_gemma":0.0000555263,"domain_scores_codex":[0.9985072,0.00006391908,0.0001944601,0.0003805458,0.000393962,0.0004599261],"domain_scores_gemma":[0.9983727,0.0002223793,0.0001039806,0.001026163,0.0001106989,0.000164112],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.002861709,0.0004927077,0.1177344,0.003182458,0.0002534312,0.002268358,0.001374056,0.0002968281,0.5760345,0.0007626621,0.08066542,0.2140734],"study_design_scores_gemma":[0.004746309,0.0001049046,0.8310807,0.001056522,0.0002266508,0.00004719196,0.0004044902,0.02388046,0.1006069,0.0006759826,0.03673336,0.0004365341],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9441637,0.02725425,0.002871035,0.00794878,0.0008212335,0.004728153,0.0001475469,0.0001107809,0.01195456],"genre_scores_gemma":[0.9904317,0.0001196674,0.0007162121,0.0001357472,0.000619624,0.0001659468,0.00004938727,0.00004790973,0.007713763],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7133462,"threshold_uncertainty_score":0.4936614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02437558049803478,"score_gpt":0.3615272800281023,"score_spread":0.3371516995300675,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}