{"id":"W2775258513","doi":"10.3390/ijms18122721","title":"Sphingosine-1-Phosphate Receptor 1, Expressed in Myeloid Cells, Slows Diet-Induced Atherosclerosis and Protects against Macrophage Apoptosis in Ldlr KO Mice","year":2017,"lang":"en","type":"article","venue":"International Journal of Molecular Sciences","topic":"Sphingolipid Metabolism and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":26,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University; Thrombosis and Atherosclerosis Research Institute","funders":"Canadian Institutes of Health Research; China Scholarship Council; McMaster University","keywords":"S1PR1; LDL receptor; Biology; Endocrinology; Sphingosine-1-phosphate; Internal medicine; Bone marrow; Sphingosine kinase; Sphingosine-1-phosphate receptor; Knockout mouse; Myeloid; Cell biology; Sphingosine; Receptor; Cancer research; Lipoprotein; Immunology; Cholesterol; Medicine; Biochemistry; Vascular endothelial growth factor A","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003248336,0.0005926469,0.0005067514,0.0006684675,0.0002147742,0.0003179762,0.0003343736,0.000561165,0.001130247],"category_scores_gemma":[0.0001869292,0.0003670494,0.0003787048,0.0001800311,0.0002948758,0.0002909737,0.0002416068,0.001075555,0.0006005481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002104319,"about_ca_system_score_gemma":0.000255812,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003162695,"about_ca_topic_score_gemma":0.000571078,"domain_scores_codex":[0.9997903,0.00003542291,0.0000358774,0.0000485699,0.00004224001,0.00004773984],"domain_scores_gemma":[0.9996926,0.00002126269,0.0001253092,0.00003215512,0.00002804646,0.0001007553],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000278231,0.00007013693,0.0002332815,0.00002436096,0.0000057383,0.00005555478,0.00001423229,0.00002826328,0.9984149,0.00006517697,0.00002814053,0.0007820375],"study_design_scores_gemma":[0.0002165166,0.001793877,0.008121828,0.00002582422,0.00006055255,0.0009308698,0.00005098433,0.001199817,0.9845312,0.0001582399,0.002895935,0.00001442029],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944047,0.0009154041,0.003314435,0.0001790193,0.00003732141,0.00004675406,0.000409984,0.0001768479,0.0005155806],"genre_scores_gemma":[0.9861445,0.001669899,0.005396449,0.0001508189,0.00003604936,0.0001681733,0.001014173,0.00009263792,0.005327196],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001130247,"threshold_uncertainty_score":0.00378108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01590528712699805,"score_gpt":0.2655848620003535,"score_spread":0.2496795748733554,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}