{"id":"W2775308736","doi":"10.1016/j.tranon.2017.11.003","title":"Cancer-Specific Inhibitory Effects of Genetically Engineered Stem Cells Expressing Cytosine Deaminase and Interferon-β Against Choriocarcinoma in Xenografted Metastatic Mouse Models","year":2017,"lang":"en","type":"article","venue":"Translational Oncology","topic":"Gestational Trophoblastic Disease Studies","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Ministry of Education, Science and Technology; National Research Foundation of Korea; National Research Foundation","keywords":"Cytosine deaminase; Suicide gene; Cancer research; Stem cell; Cancer cell; Metastasis; Molecular biology; Biology; Cancer; Haematopoiesis; Cytotoxic T cell; Interferon; Cancer stem cell; In vitro; Immunology; Genetic enhancement; Gene; Cell biology; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001742002,0.0004863456,0.0002872958,0.0003338719,0.00009716162,0.0001542567,0.0001470524,0.0002606294,0.0008429792],"category_scores_gemma":[0.0000670735,0.000137099,0.000277662,0.0001247015,0.0002099515,0.0001568251,0.00009923521,0.0007429378,0.0001481612],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002167143,"about_ca_system_score_gemma":0.0002179713,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001371252,"about_ca_topic_score_gemma":0.00217573,"domain_scores_codex":[0.9998511,0.00002434012,0.00001431252,0.00003011847,0.00004171633,0.00003841235],"domain_scores_gemma":[0.9999093,0.00001369474,0.00002006525,0.00001244511,0.00001124854,0.00003338223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001278798,0.00006481045,0.0000674562,0.00002332031,0.00000397245,0.00002734717,0.00001410464,0.00004372024,0.9990081,0.00004261113,0.00002877329,0.0005480158],"study_design_scores_gemma":[0.00003112939,0.0007907674,0.001252832,0.000004331289,0.00001646183,0.00008143197,0.00001626254,0.0005975242,0.9962738,0.00001471755,0.000918301,0.000002447342],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953401,0.001369856,0.001369083,0.00008264156,0.00004989481,0.00005876231,0.0002964991,0.00008501408,0.001348184],"genre_scores_gemma":[0.9921095,0.001232173,0.002494444,0.00005382812,0.00001338228,0.0000795689,0.0005552087,0.00002202626,0.003439852],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001371252,"threshold_uncertainty_score":0.002820075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03495005977588785,"score_gpt":0.2941036473217317,"score_spread":0.2591535875458439,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}