{"id":"W2775342436","doi":"10.1007/s00109-017-1610-9","title":"LEFTY2 inhibits endometrial receptivity by downregulating Orai1 expression and store-operated Ca2+ entry","year":2017,"lang":"en","type":"article","venue":"Journal of Molecular Medicine","topic":"Reproductive System and Pregnancy","field":"Immunology and Microbiology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Warwick Medical School; University Hospitals Coventry and Warwickshire NHS Trust; Deutsche Forschungsgemeinschaft; Home Office; University of Warwick; Eberhard Karls Universität Tübingen; European Molecular Biology Organization","keywords":"ORAI1; WNT4; Cell biology; Biology; Ionomycin; Internal medicine; Bone morphogenetic protein 2; Endocrinology; Embryo; Andrology; Chemistry; Medicine; Signal transduction; STIM1; Endoplasmic reticulum; Genetics; In vitro; Wnt signaling pathway","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00127768,0.000170604,0.000542308,0.0001385675,0.0003146774,0.00002523799,0.0002283662,0.0001873172,0.0002050851],"category_scores_gemma":[0.002350979,0.0001123293,0.00006954608,0.00006245069,0.0003259785,0.0001984054,0.00009533809,0.0003956958,0.000008409193],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002924206,"about_ca_system_score_gemma":0.00004879727,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004765703,"about_ca_topic_score_gemma":0.000001408185,"domain_scores_codex":[0.9984654,0.0004549031,0.0005157262,0.0002363083,0.0001205961,0.0002071092],"domain_scores_gemma":[0.9983056,0.0001081335,0.0009038802,0.0003759648,0.0002462819,0.00006016433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002176222,0.00004041328,0.003479373,0.00002460175,0.0001174342,0.000052758,0.000428629,0.000001307933,0.9805604,0.00002009955,0.006597826,0.008459589],"study_design_scores_gemma":[0.007554253,0.0008036796,0.01096523,0.001252591,0.00008816011,0.0007690027,0.0002239516,3.757032e-7,0.9693334,0.00006800365,0.008790348,0.0001510331],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9484684,0.04619492,0.0006102109,0.00150576,0.001725273,0.0001932984,0.000006518459,0.00000910988,0.001286454],"genre_scores_gemma":[0.9984473,0.0003065336,0.0001082551,0.00005758506,0.0003038538,0.000001801546,0.00001030735,0.00001381648,0.0007505324],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04997886,"threshold_uncertainty_score":0.4580656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01472989517959012,"score_gpt":0.2710852619708157,"score_spread":0.2563553667912256,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}