{"id":"W2775504840","doi":"10.1177/2470547017743511","title":"Hydroxynorketamine: Implications for the NMDA Receptor Hypothesis of Ketamine’s Antidepressant Action","year":2017,"lang":"en","type":"article","venue":"Chronic Stress","topic":"Treatment of Major Depression","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute on Drug Abuse","keywords":"Ketamine; Antidepressant; NMDA receptor; Neuroscience; Mechanism (biology); Mechanism of action; Psychology; Pharmacology; Hippocampus; Receptor; Medicine; Biology; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001117349,0.0001648523,0.0002808106,0.0000510027,0.0004450432,0.00003633884,0.0003673456,0.00008361237,0.0001068811],"category_scores_gemma":[0.0004254934,0.000104635,0.0001799329,0.00004204941,0.0002057661,0.0001251568,0.00008320448,0.0001004608,0.00001303291],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001376004,"about_ca_system_score_gemma":0.0001128419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009807925,"about_ca_topic_score_gemma":0.00005434466,"domain_scores_codex":[0.999039,0.00002066798,0.0002490088,0.0002918078,0.0001643076,0.0002352269],"domain_scores_gemma":[0.9974433,0.0004826569,0.0003590424,0.001526369,0.0001145911,0.00007404204],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.0003598062,0.0006245698,0.1684855,0.000638974,0.0006126912,0.000001311323,0.00008738866,0.00005221275,0.1160724,0.0003034703,0.01603512,0.6967266],"study_design_scores_gemma":[0.002284114,0.0001982031,0.7878508,0.0002912018,0.0002937736,0.000005827666,0.00003675367,0.0002612984,0.1944268,0.00006956699,0.01417784,0.0001038195],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9832314,0.002982954,0.001152743,0.007271517,0.0006518248,0.001924066,0.0003270748,0.00009724617,0.002361154],"genre_scores_gemma":[0.9950821,0.001069591,0.0006719066,0.00002639473,0.0004309282,0.0001876282,0.00004488237,0.00003429554,0.002452314],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6966227,"threshold_uncertainty_score":0.4266891,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08442289938855109,"score_gpt":0.3530391859170416,"score_spread":0.2686162865284906,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}