{"id":"W2775565028","doi":"10.1111/jpi.12462","title":"Nocturnal activation of melatonin receptor type 1 signaling modulates diurnal insulin sensitivity via regulation of <scp>PI</scp> 3K activity","year":2017,"lang":"en","type":"article","venue":"Journal of Pineal Research","topic":"Circadian rhythm and melatonin","field":"Neuroscience","cited_by":84,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Sleep & Circadian Network","funders":"National Institute on Minority Health and Health Disparities; National Center for Research Resources; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute; National Institutes of Health; Institut National de la Santé et de la Recherche Médicale; University of Massachusetts; Agence Nationale de la Recherche; National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Centre National de la Recherche Scientifique; National Eye Institute; National Heart and Lung Institute","keywords":"Melatonin; Internal medicine; Endocrinology; Insulin resistance; Insulin receptor; Insulin; Receptor; Biology; Circadian rhythm; Type 2 diabetes; Signal transduction; Diabetes mellitus; Chemistry; Medicine; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004440675,0.0001427998,0.0001227154,0.0001439492,0.00008880485,0.0001799228,0.00008164434,0.00007659121,0.0008458183],"category_scores_gemma":[0.00006219884,0.00006370691,0.0001104369,0.00007771406,0.0001219195,0.0000933833,0.0001070949,0.0002665223,0.000111435],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001833129,"about_ca_system_score_gemma":0.00009568297,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005678012,"about_ca_topic_score_gemma":0.001366012,"domain_scores_codex":[0.9999715,0.000004749881,0.000002279148,0.000007506124,0.000006322551,0.000007603721],"domain_scores_gemma":[0.9999406,0.000003468715,0.00003016483,0.000004797069,0.000004756198,0.00001611922],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003011349,0.00001252848,0.0009425765,0.00001421586,0.000005431019,0.00003281489,0.000007698758,0.00001753241,0.997276,0.00004811485,0.00003855592,0.001303351],"study_design_scores_gemma":[0.00007231806,0.0004973347,0.3299447,0.00001667594,0.00005116648,0.0004310716,0.0001012101,0.002168331,0.6638989,0.0003553786,0.002445274,0.00001750889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997419,0.0008544174,0.0008942604,0.00005800242,0.00001655473,0.000004257539,0.0002146531,0.00005071224,0.0004881816],"genre_scores_gemma":[0.9979926,0.0003912487,0.0005545674,0.00002623362,0.000006536414,0.000009178058,0.0001831506,0.00001179482,0.0008246711],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008458183,"threshold_uncertainty_score":0.002829552,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09665402605108936,"score_gpt":0.3648832565121792,"score_spread":0.2682292304610898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}