{"id":"W2775732184","doi":"10.1016/j.cell.2017.11.049","title":"FIX It in One Go: Enhanced Factor IX Gene Therapy for Hemophilia B","year":2017,"lang":"en","type":"letter","venue":"Cell","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Biology; Factor IX; Genetic enhancement; Gene; Genetics; Virology; Computational biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008949771,0.0004944759,0.0006060832,0.0003298928,0.001176911,0.001287318,0.000720689,0.0160789,0.002860472],"category_scores_gemma":[0.004149321,0.0002146772,0.0005535978,0.0001901689,0.001574056,0.001333506,0.0005061462,0.01208067,0.001911206],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002146668,"about_ca_system_score_gemma":0.0008007486,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009143279,"about_ca_topic_score_gemma":0.001613219,"domain_scores_codex":[0.9994646,0.000156988,0.00004391677,0.00005713625,0.0002015757,0.00007576164],"domain_scores_gemma":[0.9992084,0.0005690405,0.00004776523,0.0000294657,0.00006317681,0.00008223653],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003777376,0.0001781974,0.0009252744,0.0001548514,0.00004934253,0.01043822,0.000143866,0.0002870078,0.001937454,0.01590548,0.9211669,0.04843562],"study_design_scores_gemma":[0.0005387974,0.0003255715,0.0008110119,0.0001789495,0.00006530024,0.009697817,0.0002024533,0.001486166,0.002606708,0.02992052,0.9541156,0.00005120437],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"editorial","genre_scores_codex":[0.003591292,0.01077564,0.0008452118,0.9490091,0.02730145,0.00004035477,0.00006292781,0.00006880786,0.008305315],"genre_scores_gemma":[0.0551808,0.01187922,0.001385897,0.7999895,0.0945796,0.0001533069,0.00008101561,0.00006449832,0.03668619],"genre_candidate":"editorial","genre_consensus":null,"teacher_disagreement_score":0.0160789,"threshold_uncertainty_score":0.01557517,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04169940178899064,"score_gpt":0.3141768689599282,"score_spread":0.2724774671709376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}