{"id":"W2775732184","doi":"10.1016/j.cell.2017.11.049","title":"FIX It in One Go: Enhanced Factor IX Gene Therapy for Hemophilia B","year":2017,"lang":"en","type":"letter","venue":"Cell","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Queen's University","funders":"","keywords":"Biology; Factor IX; Genetic enhancement; Gene; Genetics; Virology; Computational biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002105658,0.0004024155,0.0004198081,0.0001007976,0.0001082081,0.00007040724,0.000982422,0.001139786,0.0002360515],"category_scores_gemma":[0.00003996176,0.0004022406,0.00025961,0.00004324581,0.0001153532,0.000003239622,0.0001207359,0.0006715955,0.00009836166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005186662,"about_ca_system_score_gemma":0.0002759396,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001410618,"about_ca_topic_score_gemma":0.00006719074,"domain_scores_codex":[0.9978098,0.0001096295,0.0002883855,0.0008318379,0.0002676189,0.0006927088],"domain_scores_gemma":[0.9981962,0.00004023443,0.0001867722,0.001385754,0.0001148314,0.00007621966],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006894268,0.00005461507,0.000003686787,0.0000671411,0.00004877005,0.00001441167,0.00002009754,0.000001816266,0.6362097,5.17514e-8,0.3602398,0.00265045],"study_design_scores_gemma":[0.001197178,0.00099612,0.00001032338,0.00001375127,0.000003964543,7.631187e-7,0.00000126941,0.000002069687,0.5265058,0.00002763775,0.4709916,0.0002494782],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"commentary","genre_scores_codex":[0.772061,0.009962823,0.0006136581,0.2015285,0.001075361,0.00454443,0.001523693,0.00005003863,0.008640504],"genre_scores_gemma":[0.1948038,0.009712687,0.001223497,0.537854,0.02029812,0.001560595,0.01219278,0.0007497773,0.2216047],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.5772571,"threshold_uncertainty_score":0.9998429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04169940178899064,"score_gpt":0.3141768689599282,"score_spread":0.2724774671709376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}