{"id":"W2775789737","doi":"10.1002/cyto.b.21610","title":"ICCS/ESCCA Consensus Guidelines to detect GPI‐deficient cells in Paroxysmal Nocturnal Hemoglobinuria (PNH) and related Disorders Part 2 – Reagent Selection and Assay Optimization for High‐Sensitivity Testing","year":2017,"lang":"en","type":"article","venue":"Cytometry Part B Clinical Cytometry","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":64,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre; Toronto General Hospital; University Health Network","funders":"","keywords":"Paroxysmal nocturnal hemoglobinuria; Flow cytometry; Consensus conference; Immunology; Medicine; CD59; Antibody; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.04038559,0.001591598,0.001871258,0.009141427,0.001210025,0.003543441,0.005893834,0.004785974,0.004543458],"category_scores_gemma":[0.03804075,0.001057038,0.002367487,0.003241263,0.001942659,0.001519071,0.002623755,0.003753996,0.007297225],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001923085,"about_ca_system_score_gemma":0.006800562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00631187,"about_ca_topic_score_gemma":0.007769497,"domain_scores_codex":[0.9638653,0.01388028,0.007425729,0.001085751,0.01266431,0.001078607],"domain_scores_gemma":[0.9546903,0.009751542,0.003378567,0.002334939,0.02865636,0.001188245],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000546843,0.0004600539,0.01078794,0.00624847,0.0002378049,0.0008375539,0.0007054505,0.001771584,0.02281536,0.009463757,0.5087724,0.4373529],"study_design_scores_gemma":[0.0001240566,0.0003981657,0.01889061,0.007551186,0.0002828462,0.004305015,0.0005683213,0.00229646,0.02476733,0.00582611,0.9348618,0.0001280508],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"methods","genre_scores_codex":[0.03233048,0.3577626,0.3219813,0.09009234,0.01801866,0.01204606,0.01199197,0.007299369,0.1484773],"genre_scores_gemma":[0.09280574,0.1646372,0.590911,0.04283,0.007025738,0.01411237,0.03331536,0.002198759,0.05216388],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.04038559,"threshold_uncertainty_score":0.213582,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08293413424832347,"score_gpt":0.369193162003176,"score_spread":0.2862590277548526,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}