{"id":"W2775790403","doi":"10.1126/science.aaq0939","title":"Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule","year":2018,"lang":"en","type":"article","venue":"Science","topic":"RNA regulation and disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":199,"is_retracted":false,"has_abstract":true,"ca_institutions":"Discovery Centre","funders":"Calico Life Sciences; National Institute of General Medical Sciences; National Institutes of Health; Rogers Family Foundation; Searle Scholars Program; American Asthma Foundation; Howard Hughes Medical Institute","keywords":"Translation (biology); Mechanism (biology); Biology; Biophysics; Small molecule; Cell biology; Structural biology; Chemistry; Biochemistry; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005629459,0.0001887769,0.0001649127,0.0001274859,0.0003393849,0.0002878906,0.0002578768,0.0003113677,0.001209389],"category_scores_gemma":[0.00009510153,0.0001546613,0.0001277286,0.0001201695,0.0002240333,0.000331766,0.000154095,0.0004495549,0.0005148457],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00034294,"about_ca_system_score_gemma":0.0001902502,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000689103,"about_ca_topic_score_gemma":0.0006491795,"domain_scores_codex":[0.9999868,0.000001648286,6.301028e-7,0.000004276951,0.000003501141,0.000003296283],"domain_scores_gemma":[0.9999777,0.000002349283,0.000004834908,0.000002943624,0.000003937739,0.000008210061],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004067245,0.00006101506,0.001585123,0.0002335039,0.00002418001,0.0005468022,0.0001308882,0.004209159,0.9721601,0.00855457,0.001585412,0.01050252],"study_design_scores_gemma":[0.0002944565,0.00101571,0.03889108,0.0001715258,0.0001172106,0.002868617,0.0006810354,0.1252895,0.6773102,0.0250702,0.1281731,0.0001171877],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9641711,0.009568132,0.01421459,0.001369261,0.0001553198,0.00002167154,0.0002977376,0.0002422377,0.009959964],"genre_scores_gemma":[0.9873987,0.002084597,0.005735005,0.0001676592,0.00002910936,0.00001267593,0.0008062444,0.00002517786,0.003740792],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001209389,"threshold_uncertainty_score":0.004045784,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008367179849264411,"score_gpt":0.2503820029762993,"score_spread":0.2420148231270348,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}