{"id":"W2775971119","doi":"10.1016/j.celrep.2017.12.018","title":"The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":296,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 European Research Council; Graduate School, Technische Universität München; National Science Foundation; European Research Council; Natural Sciences and Engineering Research Council of Canada; Deutsche Forschungsgemeinschaft; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Pyroptosis; Inflammasome; Caspase 1; Protease; Cell biology; Caspase; Chemistry; Caspase 8; Caspase 3; Apoptosis; Biology; Biochemistry; Programmed cell death; Enzyme; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005496102,0.0001349614,0.0001260284,0.00002067568,0.0003791883,0.000078203,0.0002638643,0.0000994611,0.000005700652],"category_scores_gemma":[0.0002845619,0.00008728624,0.00007496841,0.00002549648,0.0002471651,0.00001541557,0.0001939674,0.0001696964,0.000001128629],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000006470286,"about_ca_system_score_gemma":0.0001332143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001825634,"about_ca_topic_score_gemma":0.0001868345,"domain_scores_codex":[0.9990035,0.00007486307,0.0002752698,0.0002817049,0.0001544704,0.000210202],"domain_scores_gemma":[0.9983692,0.00002291263,0.00043825,0.001074894,0.00005517699,0.00003955603],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001254128,0.00009874117,0.04462573,0.00006269583,0.00002945652,0.0003318128,0.0004023098,0.00001106111,0.9383762,0.00001943841,0.0003604988,0.01555665],"study_design_scores_gemma":[0.0003527151,0.0001230033,0.2217535,0.00001893026,0.00001228514,0.00007316235,0.0004494315,0.00001291915,0.7600619,0.000187278,0.01678803,0.0001669107],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9941564,0.0007936595,0.000009205513,0.0002406245,0.000104665,0.0003873248,0.000004018479,0.000003163634,0.00430092],"genre_scores_gemma":[0.9985551,0.0006683089,0.00001352442,0.00003999232,0.0000418108,0.00005385245,0.000008305217,0.00001122545,0.0006078309],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1783143,"threshold_uncertainty_score":0.355943,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006132984278439346,"score_gpt":0.2260271972231835,"score_spread":0.2198942129447442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}