{"id":"W2775971119","doi":"10.1016/j.celrep.2017.12.018","title":"The Inflammasome Drives GSDMD-Independent Secondary Pyroptosis and IL-1 Release in the Absence of Caspase-1 Protease Activity","year":2017,"lang":"en","type":"article","venue":"Cell Reports","topic":"Inflammasome and immune disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":296,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"H2020 European Research Council; Graduate School, Technische Universität München; National Science Foundation; European Research Council; Natural Sciences and Engineering Research Council of Canada; Deutsche Forschungsgemeinschaft; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Pyroptosis; Inflammasome; Caspase 1; Protease; Cell biology; Caspase; Chemistry; Caspase 8; Caspase 3; Apoptosis; Biology; Biochemistry; Programmed cell death; Enzyme; Receptor","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003645117,0.0004071654,0.0004444414,0.0002564256,0.000118991,0.0004436925,0.0002413193,0.0003552001,0.001889927],"category_scores_gemma":[0.0002830307,0.0001565496,0.0003294842,0.0002091318,0.0005204568,0.0003965079,0.0003936546,0.001099293,0.0003679819],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005139246,"about_ca_system_score_gemma":0.0002619152,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001831125,"about_ca_topic_score_gemma":0.0002430038,"domain_scores_codex":[0.9996135,0.00006585645,0.00007504256,0.00009392611,0.0000797822,0.00007186923],"domain_scores_gemma":[0.9997408,0.0000517235,0.00007813748,0.00005163882,0.00002175742,0.0000558449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001758244,0.00003540537,0.0001355904,0.00006573298,0.000004553783,0.00009316923,0.00001834714,0.00008430306,0.9982646,0.0004246163,0.00003994065,0.0006579952],"study_design_scores_gemma":[0.00003410314,0.0001366624,0.0006155313,0.000003973276,0.000004756991,0.0001742103,0.00001209553,0.0004796864,0.9971938,0.00009771035,0.001244887,0.000002551562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862832,0.001058917,0.009276297,0.0002666985,0.0001289234,0.00007762153,0.001115402,0.0001250395,0.001667887],"genre_scores_gemma":[0.9942057,0.0003651157,0.00356059,0.00005106245,0.00001548133,0.00005595297,0.0005588793,0.00002326919,0.001163985],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001889927,"threshold_uncertainty_score":0.006322384,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006132984278439346,"score_gpt":0.2260271972231835,"score_spread":0.2198942129447442,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}