{"id":"W2776183812","doi":"10.1210/en.2017-03065","title":"CRISPR/Cas9‒Mediated Tspo Gene Mutations Lead to Reduced Mitochondrial Membrane Potential and Steroid Formation in MA-10 Mouse Tumor Leydig Cells","year":2017,"lang":"en","type":"article","venue":"Endocrinology","topic":"Mitochondrial Function and Pathology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":48,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre","funders":"Canadian Institutes of Health Research; National Institute on Aging; National Institutes of Health","keywords":"Translocator protein; Steroidogenic acute regulatory protein; Steroid biosynthesis; Biology; Mutant; Mitochondrion; Cell biology; Cholesterol side-chain cleavage enzyme; Inner mitochondrial membrane; Steroid; Internal medicine; Steroid hormone; Mutation; Endocrinology; Hormone; Biochemistry; Gene; Gene expression; Metabolism; Cytochrome P450","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006082474,0.0002181688,0.0002680088,0.000179476,0.0002410268,0.00006519134,0.0002764312,0.0001857132,0.0001616092],"category_scores_gemma":[0.000287716,0.000230267,0.00006732197,0.0000518469,0.0001507109,0.00002250999,0.0002073386,0.0001753624,0.000166784],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002304769,"about_ca_system_score_gemma":0.00004595782,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001054914,"about_ca_topic_score_gemma":0.0004121296,"domain_scores_codex":[0.9984107,0.0001438702,0.0003624326,0.0005130399,0.00009854849,0.0004714144],"domain_scores_gemma":[0.999016,0.00002090728,0.0001694824,0.0005751644,0.0000871996,0.0001312735],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005678482,0.00005297786,0.0000658861,0.0000105825,0.00001903868,0.0001000633,0.0001507392,0.00009129217,0.9949235,0.00002175143,0.003444953,0.0005513926],"study_design_scores_gemma":[0.002489492,0.0004402132,0.0009788859,0.000004986688,0.00002030982,0.0003694607,0.0001096263,0.0001039583,0.9781918,0.0000225344,0.01702591,0.0002428036],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9934527,0.00008017442,0.002550404,0.0008994039,0.001789065,0.0004816866,0.00008321512,0.00002854744,0.0006348015],"genre_scores_gemma":[0.9914128,0.0001167057,0.002312043,0.0005257172,0.0007325597,0.0001039507,0.0004142309,0.00003100538,0.004351056],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01673166,"threshold_uncertainty_score":0.9390016,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01447105196090591,"score_gpt":0.2622604034586009,"score_spread":0.247789351497695,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}