{"id":"W2776537462","doi":"10.1016/s1470-2045(17)30693-9","title":"Clinical trial design for systemic agents in patients with brain metastases from solid tumours: a guideline by the Response Assessment in Neuro-Oncology Brain Metastases working group","year":2017,"lang":"en","type":"review","venue":"The Lancet Oncology","topic":"Brain Metastases and Treatment","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University; Queen's University","funders":"Bayer Fund; Roche; Teva Pharmaceutical Industries; Karyopharm Therapeutics; Novartis; Dietmar Hopp Stiftung; AbbVie; Merck; GlaxoSmithKline; Pfizer; Boehringer Ingelheim; Siemens USA; AstraZeneca; National Institutes of Health; Medtronic","keywords":"Medicine; Clinical trial; Systemic therapy; Oncology; Guideline; Internal medicine; Efficacy; Regimen; Surrogate endpoint; Clinical study design; Intensive care medicine; Drug; Cancer; Pharmacology; Pathology; Breast cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.01398202,0.001047667,0.005013083,0.001006116,0.0002560955,0.002218769,0.001984717,0.002885292,0.00541217],"category_scores_gemma":[0.02000904,0.0004392448,0.004814322,0.0009761284,0.0005212345,0.001188316,0.0007478526,0.004347407,0.001348498],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001491489,"about_ca_system_score_gemma":0.002758817,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001315976,"about_ca_topic_score_gemma":0.003928408,"domain_scores_codex":[0.9938513,0.003887733,0.001123261,0.0003276631,0.0006447164,0.0001652104],"domain_scores_gemma":[0.9873229,0.009583142,0.001803246,0.0002481951,0.0007609397,0.0002816604],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.008050811,0.0002099084,0.0005855844,0.1282547,0.006255249,0.0001154705,0.0001538424,0.001400565,0.001472366,0.004755218,0.06876849,0.7799778],"study_design_scores_gemma":[0.0536763,0.004099626,0.005562593,0.1749818,0.02808354,0.0006927488,0.0002009136,0.002686805,0.001840469,0.02019445,0.7077919,0.0001888811],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"methods","genre_scores_codex":[0.00129916,0.9795659,0.003012702,0.007201543,0.001849845,0.002353112,0.001018147,0.0001104379,0.00358907],"genre_scores_gemma":[0.03609981,0.9058117,0.02110684,0.01966777,0.002113812,0.008582818,0.00222576,0.0001290944,0.004262448],"genre_candidate":"methods","genre_consensus":null,"teacher_disagreement_score":0.986018,"threshold_uncertainty_score":0.07394481,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3621266698721051,"score_gpt":0.5249072376343089,"score_spread":0.1627805677622038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}