{"id":"W2776597027","doi":"10.17615/4xr8-gp35","title":"Genetic influences on schizophrenia and subcortical brain volumes: Large-scale proof of concept","year":2016,"lang":"en","type":"article","venue":"MURAL - Maynooth University Research Archive Library (National University of Ireland, Maynooth)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Scottish Mental Health Research Network; National Center for Research Resources; National Institute of Biomedical Imaging and Bioengineering; National Institute of Mental Health; Strategic Research Council; National Health and Medical Research Council; Knut och Alice Wallenbergs Stiftelse; European Commission; Canadian Institutes of Health Research; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital; Stanley Center for Psychiatric Research, Broad Institute; National Institutes of Health; Biogen; Højteknologifonden; Ramsay Health Care; H. Lundbeck A/S; Medical Research Council; Academy of Finland; Servier; Tartu Ülikool; Uppsala Universitet; University of New South Wales; Radboud Universitair Medisch Centrum; Universitair Medisch Centrum Groningen; Biomedical Research Council; Universitetet i Bergen; Karolinska Institutet; Lundbeckfonden; Accare; National Cancer Institute; European Regional Development Fund; Max-Planck-Gesellschaft; Bergens Forskningsstiftelse; Svenska Forskningsrådet Formas; Vrije Universiteit Amsterdam; Stockholms Läns Landsting; Norges Forskningsråd; National Medical Research Council; Universiteit Leiden; Australian Schizophrenia Research Bank; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Deutsche Forschungsgemeinschaft; Genentech; Broad Institute; Australian Government; Agency for Science, Technology and Research; Northern California Institute for Research and Education; Strategiske Forskningsråd; ZonMw; Centre d'Imagerie BioMédicale; Eisai; Leids Universitair Medisch Centrum; Riksbankens Jubileumsfond; Foundation for the National Institutes of Health; National Alliance for Research on Schizophrenia and Depression; Hersenstichting; U.S. Department of Defense; Commonwealth Scientific and Industrial Research Organisation; National Institute for Health and Care Research; Pratt Foundation; NHS Blood and Transplant; Sylvia and Charles Viertel Charitable Foundation; Seventh Framework Programme; Novartis Pharmaceuticals Corporation; University of California, San Diego; Wellcome Trust; Johns Hopkins University; Pfizer; Universität Greifswald; Australian Research Council; BioClinica; University of Melbourne; Science for Life Laboratory; Akademiska Sjukhuset; Harvard University; Bundesministerium für Bildung und Forschung; Medpace; Stanley Medical Research Institute; Synarc; Max Planck Instituut voor Psycholinguïstiek; University of Southern California; Science Foundation Ireland; National Science Foundation; Scottish Funding Council; Massachusetts General Hospital; GlaxoSmithKline; Radboud Universiteit; Eli Lilly and Company; Alzheimer's Disease Neuroimaging Initiative; Max-Planck-Förderstiftung; Autism Speaks; Bristol-Myers Squibb; IXICO; Alfried Krupp von Bohlen und Halbach-Stiftung; Alzheimer's Association; British Medical Association; U.S. Department of Veterans Affairs; Vetenskapsrådet; Universiteit Utrecht; Aarhus Universitet; Meso Scale Diagnostics","keywords":"Schizophrenia (object-oriented programming); Heritability; Genetic architecture; Brain size; Genome-wide association study; Genetic association; Imaging genetics; Neuroimaging; Genetic correlation; Psychology; Genetic variation; Neuroscience; Psychiatry; Phenotype; Medicine; Genetics; Biology; Single-nucleotide polymorphism; Gene; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00921758,0.001251994,0.00108235,0.001179556,0.0008937734,0.001925268,0.001617015,0.001223966,0.006577301],"category_scores_gemma":[0.01669661,0.0008582319,0.001686862,0.001172942,0.002155816,0.001160462,0.0029306,0.001445959,0.0007763755],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005685922,"about_ca_system_score_gemma":0.001515126,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.006781152,"about_ca_topic_score_gemma":0.006706556,"domain_scores_codex":[0.9954605,0.002426272,0.0002308868,0.0009373721,0.0007008151,0.0002441227],"domain_scores_gemma":[0.9715167,0.01763211,0.002249487,0.005269185,0.001656564,0.001675883],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.02892247,0.004497644,0.6735106,0.002892146,0.02503862,0.00656392,0.003331157,0.002930509,0.0571822,0.004581485,0.01092206,0.1796272],"study_design_scores_gemma":[0.002841686,0.003012785,0.9611336,0.0002583238,0.008799159,0.002780022,0.0005778603,0.001396931,0.004140945,0.00402271,0.01089694,0.0001389404],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9512876,0.01054225,0.02280924,0.002833478,0.0003327187,0.0006738106,0.005808453,0.0003967701,0.005315739],"genre_scores_gemma":[0.9683179,0.003550446,0.02141579,0.001279823,0.0002758375,0.0005525694,0.003289208,0.0002257857,0.001092514],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00921758,"threshold_uncertainty_score":0.04874778,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01497273216591578,"score_gpt":0.2451096363696843,"score_spread":0.2301369042037685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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