{"id":"W2776597027","doi":"10.17615/4xr8-gp35","title":"Genetic influences on schizophrenia and subcortical brain volumes: Large-scale proof of concept","year":2016,"lang":"en","type":"article","venue":"MURAL - Maynooth University Research Archive Library (National University of Ireland, Maynooth)","topic":"Genetic Associations and Epidemiology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Scottish Mental Health Research Network; National Center for Research Resources; National Institute of Biomedical Imaging and Bioengineering; National Institute of Mental Health; Strategic Research Council; National Health and Medical Research Council; Knut och Alice Wallenbergs Stiftelse; European Commission; Canadian Institutes of Health Research; Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital; Stanley Center for Psychiatric Research, Broad Institute; National Institutes of Health; Biogen; Højteknologifonden; Ramsay Health Care; H. Lundbeck A/S; Medical Research Council; Academy of Finland; Servier; Tartu Ülikool; Uppsala Universitet; University of New South Wales; Radboud Universitair Medisch Centrum; Universitair Medisch Centrum Groningen; Biomedical Research Council; Universitetet i Bergen; Karolinska Institutet; Lundbeckfonden; Accare; National Cancer Institute; European Regional Development Fund; Max-Planck-Gesellschaft; Bergens Forskningsstiftelse; Svenska Forskningsrådet Formas; Vrije Universiteit Amsterdam; Stockholms Läns Landsting; Norges Forskningsråd; National Medical Research Council; Universiteit Leiden; Australian Schizophrenia Research Bank; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Deutsche Forschungsgemeinschaft; Genentech; Broad Institute; Australian Government; Agency for Science, Technology and Research; Northern California Institute for Research and Education; Strategiske Forskningsråd; ZonMw; Centre d'Imagerie BioMédicale; Eisai; Leids Universitair Medisch Centrum; Riksbankens Jubileumsfond; Foundation for the National Institutes of Health; National Alliance for Research on Schizophrenia and Depression; Hersenstichting; U.S. Department of Defense; Commonwealth Scientific and Industrial Research Organisation; National Institute for Health and Care Research; Pratt Foundation; NHS Blood and Transplant; Sylvia and Charles Viertel Charitable Foundation; Seventh Framework Programme; Novartis Pharmaceuticals Corporation; University of California, San Diego; Wellcome Trust; Johns Hopkins University; Pfizer; Universität Greifswald; Australian Research Council; BioClinica; University of Melbourne; Science for Life Laboratory; Akademiska Sjukhuset; Harvard University; Bundesministerium für Bildung und Forschung; Medpace; Stanley Medical Research Institute; Synarc; Max Planck Instituut voor Psycholinguïstiek; University of Southern California; Science Foundation Ireland; National Science Foundation; Scottish Funding Council; Massachusetts General Hospital; GlaxoSmithKline; Radboud Universiteit; Eli Lilly and Company; Alzheimer's Disease Neuroimaging Initiative; Max-Planck-Förderstiftung; Autism Speaks; Bristol-Myers Squibb; IXICO; Alfried Krupp von Bohlen und Halbach-Stiftung; Alzheimer's Association; British Medical Association; U.S. Department of Veterans Affairs; Vetenskapsrådet; Universiteit Utrecht; Aarhus Universitet; Meso Scale Diagnostics","keywords":"Schizophrenia (object-oriented programming); Heritability; Genetic architecture; Brain size; Genome-wide association study; Genetic association; Imaging genetics; Neuroimaging; Genetic correlation; Psychology; Genetic variation; Neuroscience; Psychiatry; Phenotype; Medicine; Genetics; Biology; Single-nucleotide polymorphism; Gene; Genotype","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000280091,0.0001481552,0.0002440021,0.0003032855,0.0002377825,0.000008321314,0.0004396164,0.0001582621,0.0003753846],"category_scores_gemma":[0.0002213494,0.0001368972,0.0001102398,0.0002256888,0.001080345,0.000042886,0.0004980155,0.0001580398,0.00001328735],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002806856,"about_ca_system_score_gemma":0.0002739928,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008542203,"about_ca_topic_score_gemma":0.0001419269,"domain_scores_codex":[0.9981182,0.0005242273,0.0001761097,0.0004395606,0.0003714574,0.0003704962],"domain_scores_gemma":[0.9988737,0.0004125669,0.0001431529,0.0002198161,0.0001561259,0.0001946581],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.003929119,0.000618352,0.8343002,0.00009049463,0.0004223116,0.00005743699,0.0006965978,0.0003826382,0.03577495,0.02035612,0.09452357,0.008848195],"study_design_scores_gemma":[0.005594178,0.00192348,0.899966,0.0001350482,0.00003574248,0.00001336367,0.00190236,0.001113351,0.003492552,0.004369042,0.08101958,0.0004352749],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9806263,0.0001145105,0.004075708,0.002173764,0.00002048477,0.0002749195,0.0007003564,0.00001624118,0.01199774],"genre_scores_gemma":[0.9816058,0.0002134176,0.005325036,0.00006794561,0.00005593146,2.72613e-7,0.00009725501,0.00001758115,0.01261676],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06566582,"threshold_uncertainty_score":0.5582506,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01497273216591578,"score_gpt":0.2451096363696843,"score_spread":0.2301369042037685,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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