{"id":"W2776686103","doi":"10.1073/pnas.1711141115","title":"Epigenetic control of pheromone MAPK signaling determines sexual fecundity in <i>Candida albicans</i>","year":2017,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Antifungal resistance and susceptibility","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Concordia University","funders":"National Institute of Dental and Craniofacial Research; National Institute of Allergy and Infectious Diseases; National Institutes of Health; National Institute of General Medical Sciences; Burroughs Wellcome Fund","keywords":"Candida albicans; Epigenetics; Biology; MAPK/ERK pathway; Signal transduction; Cell biology; Sexual reproduction; Mating; Carcinogenesis; Genetics; Cancer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009560544,0.000142339,0.00009958557,0.0001850741,0.0001673906,0.0004093577,0.0001676441,0.000126472,0.001718944],"category_scores_gemma":[0.0002252836,0.000116978,0.0001394745,0.00009780013,0.0002077547,0.0001273596,0.0002727617,0.0003537076,0.0002774024],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002973622,"about_ca_system_score_gemma":0.0002462864,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001396383,"about_ca_topic_score_gemma":0.002273855,"domain_scores_codex":[0.9999137,0.000007417086,0.000006958424,0.00002527671,0.00002358467,0.00002309249],"domain_scores_gemma":[0.9998611,0.00002204592,0.00004614379,0.00001445933,0.00002432975,0.00003192969],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008047172,0.000008824718,0.001159284,0.000008823683,0.000002372189,0.00002622446,0.0000186116,0.00006164728,0.9968093,0.0001612082,0.0000415091,0.001621732],"study_design_scores_gemma":[0.00001326894,0.0001404378,0.06993324,0.000007769367,0.00002199196,0.0003249653,0.000138236,0.001774781,0.925605,0.0002319139,0.001790032,0.0000184202],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971636,0.0001841353,0.0008550916,0.00005710424,0.00001070343,0.000005724936,0.0002820871,0.00004224584,0.001399369],"genre_scores_gemma":[0.9983999,0.00009155742,0.0003994997,0.00003728016,0.000003220462,0.000005722148,0.0001954664,0.00002104745,0.0008463944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001718944,"threshold_uncertainty_score":0.005750418,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05093871167656795,"score_gpt":0.339249677389406,"score_spread":0.288310965712838,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}