{"id":"W2776825260","doi":"10.30699/mmlj17.1.3.107","title":"New Platforms For Drug Screening And Toxicology: Necessity Or Need?","year":2018,"lang":"en","type":"article","venue":"Modern Medical Laboratory Journal","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Drug; Drug metabolism; Biotransformation; Xenobiotic; Pharmacology; Biology; Risk analysis (engineering); Computational biology; Toxicology; Medicine; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.002812273,0.0003026524,0.0004438563,0.000153859,0.0009450632,0.00008275812,0.0005188837,0.0005235014,0.004563093],"category_scores_gemma":[0.0006267254,0.0002231417,0.00009834233,0.0002436228,0.0004751777,0.0002583208,0.0001816145,0.001532427,0.00003321045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003943506,"about_ca_system_score_gemma":0.001158442,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004890816,"about_ca_topic_score_gemma":0.00004412853,"domain_scores_codex":[0.9975545,0.000235867,0.0005778927,0.0003654477,0.0004976217,0.0007687084],"domain_scores_gemma":[0.9966892,0.0005024053,0.0002476751,0.0001547789,0.0003567118,0.002049243],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.003480227,0.0003501847,0.008416679,0.0000721387,0.0005918154,0.0003165265,0.002987353,0.00005323963,0.02403623,0.001339725,0.2421675,0.7161884],"study_design_scores_gemma":[0.008953578,0.0003659074,0.001075547,0.00005152529,0.0003132013,0.0004041768,0.0002051464,0.03326538,0.02367331,0.009148085,0.9220304,0.0005137476],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8757837,0.005718302,0.1064512,0.00626479,0.004463846,0.0004248615,0.00012949,0.0001020918,0.0006616405],"genre_scores_gemma":[0.930048,0.002541262,0.01822845,0.03477198,0.01208105,0.00003761915,0.00001556363,0.00009937703,0.002176736],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7156746,"threshold_uncertainty_score":0.9963469,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09705772068852357,"score_gpt":0.4386718224724832,"score_spread":0.3416141017839596,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}