{"id":"W2776875854","doi":"10.1016/j.neulet.2017.12.049","title":"Elevated nuclear phosphatase and tensin homolog (PTEN) and altered insulin signaling in substantia nigral region of patients with Parkinson’s disease","year":2017,"lang":"en","type":"article","venue":"Neuroscience Letters","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Saskatchewan","funders":"National Institutes of Health","keywords":"PTEN; Tensin; Endocrinology; Insulin receptor; Internal medicine; IRS1; Insulin resistance; PI3K/AKT/mTOR pathway; Biology; Insulin; Pathogenesis; Phosphatidylinositol; Medicine; Signal transduction; Cell biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002128064,0.0004408978,0.0004141672,0.001428916,0.0007406051,0.0006596715,0.0003656632,0.0007438556,0.001495519],"category_scores_gemma":[0.0007981958,0.0003479515,0.0003055166,0.0008029501,0.000566326,0.0003512132,0.0003863373,0.0004163121,0.0001676217],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003322047,"about_ca_system_score_gemma":0.0002479058,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002804807,"about_ca_topic_score_gemma":0.003729797,"domain_scores_codex":[0.9998403,0.00002117036,0.00003120968,0.00003749672,0.00004662458,0.00002325588],"domain_scores_gemma":[0.9997229,0.00004406172,0.000121363,0.00001359815,0.00004481342,0.00005330609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001883632,0.0001886581,0.9141566,0.00008969385,0.0002712752,0.03105595,0.0006361997,0.000193386,0.04176631,0.0002040053,0.0002969313,0.009257371],"study_design_scores_gemma":[0.00002974103,0.0001948718,0.9647369,0.00001233502,0.0001785897,0.03145231,0.0003656938,0.0005074426,0.001859695,0.0003122788,0.0003359304,0.0000142435],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9987906,0.000368324,0.0001075549,0.0000826879,0.000005170961,0.000004019613,0.00006258675,0.000008229043,0.0005709754],"genre_scores_gemma":[0.9995635,0.0001085703,0.0000824111,0.00003012152,0.000007515781,0.000002208264,0.00006159793,0.000001748587,0.0001423191],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002804807,"threshold_uncertainty_score":0.005576968,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01659133656329274,"score_gpt":0.2299274249638485,"score_spread":0.2133360884005557,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}