{"id":"W2776876821","doi":"","title":"New insights in the cause of inhibitor development in hemophilia A: the Arg593->Cys mutation and high dose of factor VIII may be the culprits.","year":2009,"lang":"en","type":"article","venue":"","topic":"Hemophilia Treatment and Research","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Institute of Infection and Immunity","funders":"","keywords":"Mutation; Medicine; Genetics; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003972616,0.0007023746,0.0007532717,0.0008547736,0.0003052948,0.0010384,0.0007406383,0.003364281,0.004773206],"category_scores_gemma":[0.0010795,0.000224438,0.0004503851,0.0004370275,0.0008543977,0.001712354,0.0003150366,0.001959151,0.0009913311],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004125664,"about_ca_system_score_gemma":0.0003652679,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000671241,"about_ca_topic_score_gemma":0.0004561319,"domain_scores_codex":[0.9998118,0.00003660235,0.00002352024,0.00004080165,0.00004523711,0.00004197868],"domain_scores_gemma":[0.9996365,0.0001683766,0.0000812752,0.00001894399,0.00004553303,0.00004932501],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.005971223,0.001495882,0.1130505,0.001484229,0.0008213334,0.2873486,0.001127213,0.003469612,0.1443517,0.07453336,0.0524809,0.3138655],"study_design_scores_gemma":[0.001130854,0.001787317,0.07672801,0.0005169201,0.001199846,0.6020614,0.001217629,0.0151702,0.06165841,0.09612521,0.1421883,0.0002159344],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.602879,0.2381228,0.02719375,0.08357488,0.003246713,0.00009126384,0.0009113146,0.0005069679,0.04347319],"genre_scores_gemma":[0.9442568,0.03962632,0.004701579,0.004597621,0.003024493,0.00001785698,0.0002272248,0.00003684611,0.003511245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004773206,"threshold_uncertainty_score":0.01596797,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03872135670736902,"score_gpt":0.3098126898345077,"score_spread":0.2710913331271386,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}