{"id":"W2776935753","doi":"10.1002/cmdc.201700601","title":"Designing Dual Transglutaminase 2/Histone Deacetylase Inhibitors Effective at Halting Neuronal Death","year":2017,"lang":"en","type":"article","venue":"ChemMedChem","topic":"Blood properties and coagulation","field":"Medicine","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"Associazione Italiana per la Ricerca sul Cancro","keywords":"HDAC6; HDAC1; Histone deacetylase; Tissue transglutaminase; Glutamate receptor; Chemistry; Histone deacetylase 2; In vitro; HDAC11; HDAC10; Pharmacology; Biochemistry; Histone; Cell biology; Enzyme; Biology; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002208058,0.000170883,0.0003137563,0.00004034438,0.0003883875,0.00001903033,0.00008804413,0.0001088923,0.00005408889],"category_scores_gemma":[0.0002427432,0.0001497385,0.00013295,0.00003445639,0.0001528754,0.0001181926,0.00007624331,0.0001849962,0.00001829391],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001057412,"about_ca_system_score_gemma":0.00005301048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007170648,"about_ca_topic_score_gemma":0.000005973668,"domain_scores_codex":[0.9989616,0.00002517923,0.0002483582,0.0002743942,0.0002409612,0.0002495529],"domain_scores_gemma":[0.9991022,0.00006919639,0.0002025842,0.0003916638,0.00008751563,0.000146823],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004583767,0.0001371229,0.01438323,0.0002491005,0.00006319922,0.0000582136,0.001116417,0.00000597198,0.960989,0.00003456003,0.0002099406,0.02229487],"study_design_scores_gemma":[0.001892478,0.000245066,0.04597286,0.0002043934,0.0001589473,0.00006916199,0.00009088542,0.0002547295,0.9507635,0.0000194748,0.0001898042,0.0001387527],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953236,0.0003387476,0.0001885999,0.0004483351,0.0001446285,0.0003690351,0.00000322072,0.00004441017,0.00313944],"genre_scores_gemma":[0.9977306,0.000008805853,0.001031699,0.00009000645,0.0002600106,0.00003306416,0.0000137357,0.00003326218,0.0007988687],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03158963,"threshold_uncertainty_score":0.610616,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03286230096711342,"score_gpt":0.2913549580468541,"score_spread":0.2584926570797407,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}