{"id":"W2777079342","doi":"10.1016/j.phrs.2017.12.024","title":"Implication of STARD5 and cholesterol homeostasis disturbance in the endoplasmic reticulum stress-related response induced by pro-apoptotic aminosteroid RM-133","year":2017,"lang":"en","type":"article","venue":"Pharmacological Research","topic":"Endoplasmic Reticulum Stress and Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":11,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Sherbrooke; Université Laval","funders":"Mitacs; Northeast Ohio Medical University","keywords":"Endoplasmic reticulum; Apoptosis; Homeostasis; Unfolded protein response; Chemistry; In vitro; Cell biology; Cancer research; Pharmacology; Biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001469387,0.0001803113,0.0002134669,0.00006941989,0.0003255712,0.0001254508,0.0007821789,0.000177708,0.00002653866],"category_scores_gemma":[0.001503252,0.0001238441,0.00006331714,0.0001229266,0.0006598505,0.00001774018,0.0004266366,0.0004574144,0.000005822883],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002653344,"about_ca_system_score_gemma":0.0000784166,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000723661,"about_ca_topic_score_gemma":0.00001523365,"domain_scores_codex":[0.9972089,0.0009577691,0.0003393212,0.0005444413,0.0004593032,0.0004902481],"domain_scores_gemma":[0.9985666,0.0003106978,0.0001674367,0.0006207323,0.0001635961,0.0001709793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001482231,0.0003701891,0.02375678,0.00005186435,0.00003590429,0.00001542466,0.0001280746,0.000004035219,0.9707394,0.00005038173,0.0008517033,0.002514072],"study_design_scores_gemma":[0.001942561,0.0007531234,0.3159484,0.0000380344,0.00002438537,0.000007606554,0.000204463,0.00009265021,0.6799767,0.0001274817,0.0007275492,0.0001570277],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956572,0.0008695929,0.000004431522,0.001911251,0.00004295429,0.0008544759,0.0001556433,0.00000676267,0.0004976895],"genre_scores_gemma":[0.9983055,0.001121411,0.0000142224,0.0000918322,0.00003510207,0.0002525937,0.00006539579,0.00001411743,0.00009980739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2921917,"threshold_uncertainty_score":0.5050216,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05595253938802197,"score_gpt":0.3956911696514661,"score_spread":0.3397386302634441,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}