{"id":"W2777126842","doi":"10.3390/pathogens7010004","title":"The Evolutionary unZIPping of a Dimerization Motif—A Comparison of ZIP and PrP Architectures","year":2017,"lang":"en","type":"article","venue":"Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto; University of Alberta","funders":"Alberta Prion Research Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Ectodomain; Transporter; Structural motif; Recombinant DNA; Biology; Cysteine; Prion protein; Protein structure; Chemistry; Computational biology; Biochemistry; Gene; Receptor; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001178996,0.0001155402,0.0001330679,0.0002847033,0.0002266992,0.0002917898,0.0001970106,0.0002383453,0.0005681048],"category_scores_gemma":[0.0001735536,0.000103424,0.0001072309,0.0001760975,0.0002740559,0.0004145431,0.0002617979,0.0003245568,0.0003118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001355668,"about_ca_system_score_gemma":0.0001186753,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001763161,"about_ca_topic_score_gemma":0.0002743417,"domain_scores_codex":[0.9999403,0.00001186634,0.000004050325,0.00001436237,0.00001717539,0.00001228259],"domain_scores_gemma":[0.9999064,0.00001122244,0.00002776941,0.0000125907,0.00001504773,0.00002697378],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002246766,0.00001848186,0.004279501,0.00005607384,0.0000127473,0.000524098,0.0001957994,0.0003054311,0.9841511,0.002101814,0.00009483823,0.008035379],"study_design_scores_gemma":[0.00008980891,0.001985205,0.4861898,0.00007579694,0.0001427993,0.02407846,0.00167103,0.01600379,0.4223393,0.01091582,0.03639062,0.0001175865],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952523,0.0006682648,0.00210405,0.00007019522,0.000004875828,0.000006780465,0.00005248357,0.00002779516,0.001813251],"genre_scores_gemma":[0.9969379,0.0003553049,0.001904244,0.00005923312,0.00000695057,0.000005131044,0.0001442512,0.00001015707,0.0005768529],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005681048,"threshold_uncertainty_score":0.001900434,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01415828140953731,"score_gpt":0.2923280134178278,"score_spread":0.2781697320082905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}