{"id":"W2777126842","doi":"10.3390/pathogens7010004","title":"The Evolutionary unZIPping of a Dimerization Motif—A Comparison of ZIP and PrP Architectures","year":2017,"lang":"en","type":"article","venue":"Pathogens","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Occupational Cancer Research Centre; University of Toronto; University of Alberta","funders":"Alberta Prion Research Institute; Canadian Institutes of Health Research; National Institutes of Health","keywords":"Ectodomain; Transporter; Structural motif; Recombinant DNA; Biology; Cysteine; Prion protein; Protein structure; Chemistry; Computational biology; Biochemistry; Gene; Receptor; Enzyme; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008503646,0.00005074306,0.00007476043,0.000010683,0.0002295053,0.00001178147,0.0001262384,0.00003640295,0.000002297217],"category_scores_gemma":[0.0002040664,0.00003859096,0.00004095805,0.00001265701,0.0001260758,0.000001193382,0.0001094548,0.00002562701,1.540432e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000001685494,"about_ca_system_score_gemma":0.00002134397,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001213372,"about_ca_topic_score_gemma":0.000007980087,"domain_scores_codex":[0.9996076,0.00003219755,0.000119365,0.0001016169,0.00006320386,0.00007604694],"domain_scores_gemma":[0.9994912,0.00001409797,0.0001626595,0.0002658115,0.00003984763,0.0000264017],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00004350581,0.00001847782,0.07464675,0.00002851517,0.00002577459,2.013542e-7,0.00006608,0.0001439095,0.8767024,0.0001422904,0.00003613317,0.04814592],"study_design_scores_gemma":[0.000397005,0.0001928467,0.54144,0.00007331549,0.00004491824,0.00000478222,0.0001352104,0.002270005,0.4492151,0.0007977986,0.005281556,0.000147526],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9862532,0.01201223,0.001342717,0.00007190966,0.00004001584,0.00009875352,0.0000329923,0.000002137696,0.0001460741],"genre_scores_gemma":[0.9987802,0.0006277548,0.0005027868,0.000008285641,0.0000422454,0.000005191842,0.00001480817,0.000004974339,0.00001377635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4667932,"threshold_uncertainty_score":0.1765192,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01415828140953731,"score_gpt":0.2923280134178278,"score_spread":0.2781697320082905,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}