{"id":"W2777201560","doi":"10.1021/acssynbio.7b00323","title":"Antibody-Based Fusion Proteins Allow Ca<sup>2+</sup> Rewiring to Most Extracellular Ligands","year":2017,"lang":"en","type":"article","venue":"ACS Synthetic Biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute","keywords":"Extracellular; Fusion protein; Cell biology; Biology; mCherry; Signal transduction; Cytoplasm; Protein engineering; Biochemistry; Green fluorescent protein; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005363966,0.0002925212,0.0005293443,0.0001820238,0.0006298025,0.00006235712,0.0005522631,0.0003070384,0.0005267222],"category_scores_gemma":[0.0006872399,0.0002180902,0.0001446851,0.000108159,0.0004179226,0.00005466678,0.0003586173,0.0004191487,0.0006717101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004965959,"about_ca_system_score_gemma":0.0001910395,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009654541,"about_ca_topic_score_gemma":0.00002913715,"domain_scores_codex":[0.9979036,0.00008032424,0.0003595509,0.0006144302,0.0002929745,0.0007490673],"domain_scores_gemma":[0.9980726,0.0001526959,0.0001160907,0.001090056,0.0001689497,0.0003996257],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0007705932,0.0002599699,0.02305542,0.000173947,0.00008884906,0.000299307,0.0003151188,0.00005763254,0.9522163,0.0006860834,0.0005808265,0.02149598],"study_design_scores_gemma":[0.003376955,0.003765787,0.01809748,0.001203494,0.0001765931,0.0003980154,0.0002001987,0.01978806,0.4657447,0.0008380332,0.4853341,0.001076598],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9653214,0.0004787157,0.001275236,0.02724784,0.0001560413,0.0008238498,0.00005171251,0.0000623163,0.004582862],"genre_scores_gemma":[0.9904511,0.0001339123,0.001711218,0.001066903,0.0003892902,0.00006694275,0.000162989,0.00003941196,0.005978221],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4864716,"threshold_uncertainty_score":0.8893461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0317247489486515,"score_gpt":0.3379837586613923,"score_spread":0.3062590097127408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}