{"id":"W2777201560","doi":"10.1021/acssynbio.7b00323","title":"Antibody-Based Fusion Proteins Allow Ca<sup>2+</sup> Rewiring to Most Extracellular Ligands","year":2017,"lang":"en","type":"article","venue":"ACS Synthetic Biology","topic":"Monoclonal and Polyclonal Antibodies Research","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Cancer Society Research Institute","keywords":"Extracellular; Fusion protein; Cell biology; Biology; mCherry; Signal transduction; Cytoplasm; Protein engineering; Biochemistry; Green fluorescent protein; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002231109,0.0004256894,0.0002532766,0.0001602242,0.0001446126,0.0004983841,0.0003780797,0.0006237451,0.001855119],"category_scores_gemma":[0.0002141289,0.0001893442,0.000289618,0.0001511386,0.0003084504,0.000270621,0.0002850025,0.0006463468,0.0008610122],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004760441,"about_ca_system_score_gemma":0.0001881428,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003953184,"about_ca_topic_score_gemma":0.0005291228,"domain_scores_codex":[0.9998121,0.0000213564,0.0000145333,0.00005389005,0.00005993378,0.00003818761],"domain_scores_gemma":[0.9998831,0.000023533,0.00003524678,0.00001430914,0.00002081648,0.000022943],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002443204,0.000007532955,0.00003809349,0.00002264396,0.000003822798,0.00002491525,0.00000641308,0.00007482189,0.9981607,0.0004118199,0.0001642209,0.00106076],"study_design_scores_gemma":[0.00001313461,0.00006765231,0.0004563029,0.000004809019,0.00001348329,0.0001728223,0.000007660949,0.0008553889,0.9829528,0.0001271945,0.0153232,0.00000549246],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8530318,0.005808708,0.1189251,0.001439041,0.0004274265,0.0002511526,0.001300417,0.001328346,0.01748807],"genre_scores_gemma":[0.9428591,0.002036487,0.03915185,0.0005663281,0.00005440429,0.0001719077,0.001299844,0.0001381122,0.01372211],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001855119,"threshold_uncertainty_score":0.006205916,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0317247489486515,"score_gpt":0.3379837586613923,"score_spread":0.3062590097127408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}