{"id":"W2777240184","doi":"10.3389/fncel.2017.00412","title":"The Oxidative Stress-Induced Increase in the Membrane Expression of the Water-Permeable Channel Aquaporin-4 in Astrocytes Is Regulated by Caveolin-1 Phosphorylation","year":2017,"lang":"en","type":"article","venue":"Frontiers in Cellular Neuroscience","topic":"Caveolin-1 and cellular processes","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Oxidative stress; Aquaporin 4; Gene knockdown; Caveolin 1; Cell biology; Reactive oxygen species; Astrocyte; Chemistry; Phosphorylation; Downregulation and upregulation; Oxidative phosphorylation; Biochemistry; Biology; Endocrinology; Central nervous system","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007436874,0.0001954681,0.0001838478,0.00005448752,0.000457513,0.0001078724,0.00144183,0.0001312908,0.000002111544],"category_scores_gemma":[0.0002946884,0.00009875855,0.00006954015,0.0001973414,0.00043787,0.00003468459,0.0003101736,0.0002531805,5.693735e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002539971,"about_ca_system_score_gemma":0.000080622,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003636076,"about_ca_topic_score_gemma":0.0001315936,"domain_scores_codex":[0.9981895,0.0002151205,0.0003418341,0.0004944708,0.0003502524,0.0004087875],"domain_scores_gemma":[0.9986894,0.00002289422,0.0002415447,0.0009493174,0.00005311199,0.00004379846],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001165462,0.00009107419,0.006688708,0.00001678175,0.000001637909,0.00000660372,0.0005557699,0.0002921941,0.9916867,0.000003450931,0.0002954633,0.0002450664],"study_design_scores_gemma":[0.0005171639,0.00007003471,0.003219252,0.0000524816,0.000005131187,0.000002588182,0.0005615963,0.002475762,0.991667,0.0001065184,0.001187245,0.0001351834],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9974604,0.0006659891,0.0004351606,0.0003753587,0.0004978126,0.0003925921,0.00002134405,0.000003329477,0.0001480699],"genre_scores_gemma":[0.9987133,0.00036183,0.00002826155,0.0001235778,0.00003570318,0.00003302704,0.00002294713,0.00001445168,0.0006668668],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003469456,"threshold_uncertainty_score":0.4027257,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009586785878661552,"score_gpt":0.2233815533800825,"score_spread":0.2137947675014209,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}