{"id":"W2777648031","doi":"10.1186/s13023-017-0738-6","title":"Exploring patient and family involvement in the lifecycle of an orphan drug: a scoping review","year":2017,"lang":"en","type":"review","venue":"Orphanet Journal of Rare Diseases","topic":"Genomics and Rare Diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Orphan drug; Human genetics; Drug discovery; Drug; Medicine; Business; Knowledge management; Pharmacology; Bioinformatics; Genetics; Computer science; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003944734,0.000313843,0.001111157,0.0001233049,0.00008538579,0.00006313285,0.0006132909,0.00006547129,0.000007818168],"category_scores_gemma":[0.0001904816,0.0002026083,0.0004484436,0.00007402829,0.00008554055,0.00002668427,0.000164056,0.0001359003,7.941238e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001746085,"about_ca_system_score_gemma":0.0005930354,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001318844,"about_ca_topic_score_gemma":0.00001706051,"domain_scores_codex":[0.9979507,0.0003648312,0.0009160538,0.0002753731,0.0002835666,0.0002094584],"domain_scores_gemma":[0.9977221,0.00004708819,0.001337784,0.0005632475,0.0001366543,0.000193161],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006492575,0.0004613007,0.00010494,0.07571208,0.0002645206,0.0004294471,0.0001233636,0.000004753893,0.00003323365,0.000004545166,0.001005674,0.9217912],"study_design_scores_gemma":[0.0006953253,0.0009136265,0.0002928013,0.4413483,0.002106443,0.0004085975,0.0005894528,6.79063e-7,0.00004680333,0.00002069589,0.5529501,0.0006271701],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02945388,0.9694222,9.640318e-7,0.00001532605,0.0001887227,0.0007155763,0.0001861819,0.000001419968,0.00001573639],"genre_scores_gemma":[0.004365801,0.9948854,0.00003946757,0.0001643032,0.0002320104,0.00007189113,0.0002046711,0.00003158908,0.000004904347],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.921164,"threshold_uncertainty_score":0.8262125,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0969796574344712,"score_gpt":0.3389881943018784,"score_spread":0.2420085368674072,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}