{"id":"W2778060779","doi":"10.21769/bioprotoc.2650","title":"Generation of Busulfan Chimeric Mice for the Analysis of T Cell Population Dynamics","year":2017,"lang":"en","type":"article","venue":"BIO-PROTOCOL","topic":"T-cell and B-cell Immunology","field":"Immunology and Microbiology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"Medical Research Council; National Institutes of Health","keywords":"Busulfan; Biology; Population; Haematopoiesis; Bone marrow; Immunology; Immune system; Congenic; Transplantation; Stem cell; Cancer research; Hematopoietic stem cell transplantation; Cell biology; Medicine; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001157328,0.001730283,0.0007552289,0.002834241,0.001221119,0.001175018,0.001855149,0.00178706,0.02505297],"category_scores_gemma":[0.0003730907,0.001403751,0.001024088,0.0008164179,0.0005707513,0.0009451431,0.0008684327,0.004528116,0.01171412],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000988449,"about_ca_system_score_gemma":0.0008501124,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00102427,"about_ca_topic_score_gemma":0.002955307,"domain_scores_codex":[0.9991782,0.0000917457,0.00008763425,0.0002466131,0.0001842812,0.0002115068],"domain_scores_gemma":[0.9995909,0.00005245386,0.0000851826,0.00009824731,0.00005893661,0.0001141462],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004618131,0.0001728796,0.0001933612,0.000118983,0.00001948074,0.00006097878,0.00007515935,0.0001470697,0.9911514,0.001821869,0.001711308,0.004065637],"study_design_scores_gemma":[0.0002054018,0.0003241244,0.001707186,0.00004895549,0.00004697603,0.0002671025,0.00003775746,0.001621881,0.967304,0.0004441383,0.02796932,0.00002318018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"protocol","genre_scores_codex":[0.4690626,0.004203868,0.3459361,0.001510511,0.001685762,0.01048586,0.1213124,0.00943633,0.03636666],"genre_scores_gemma":[0.4486484,0.005050717,0.2673098,0.001024469,0.0002684609,0.02383347,0.1237177,0.003574101,0.1265729],"genre_candidate":"protocol","genre_consensus":null,"teacher_disagreement_score":0.02505297,"threshold_uncertainty_score":0.08381051,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0361254128866658,"score_gpt":0.3048638767788681,"score_spread":0.2687384638922022,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}