{"id":"W2778185998","doi":"10.1503/cmaj.170561","title":"Newborn screening for severe combined immunodeficiency: a primer for clinicians","year":2017,"lang":"en","type":"review","venue":"Canadian Medical Association Journal","topic":"Immunodeficiency and Autoimmune Disorders","field":"Immunology and Microbiology","cited_by":34,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine; BC Children's Hospital; SickKids Foundation; Dalhousie University; University of Toronto; University of British Columbia; Hospital for Sick Children; Izaak Walton Killam Health Centre","funders":"National Institute of Allergy and Infectious Diseases","keywords":"Severe combined immunodeficiency; Immune system; Immunodeficiency; Primer (cosmetics); Primary immunodeficiency; Immunologic Deficiency Syndromes; Medicine; Hematopoietic cell; Haematopoiesis; Hematopoietic stem cell transplantation; Immunology; Newborn screening; Stem cell; Human immunodeficiency virus (HIV); Intensive care medicine; Bioinformatics; Pediatrics; Biology; Transplantation; Internal medicine; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","sts","research_integrity","insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.004364281,0.0005107124,0.001978528,0.0003995576,0.002717051,0.0002164585,0.001507805,0.002652357,0.0009775852],"category_scores_gemma":[0.006178033,0.0004504501,0.001561605,0.0001590966,0.0001827417,0.0001634281,0.00005590041,0.002246807,0.0002791923],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006947438,"about_ca_system_score_gemma":0.01033573,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001041226,"about_ca_topic_score_gemma":0.0008464865,"domain_scores_codex":[0.9959068,0.0004225483,0.00158452,0.0004579996,0.0002309684,0.001397203],"domain_scores_gemma":[0.9955274,0.001269808,0.002018197,0.000445894,0.0005939276,0.0001447484],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000227896,0.00004979764,0.00000984363,0.0004189712,0.0008014701,0.000006752869,0.000109936,5.78486e-7,4.678115e-7,0.0001790516,0.02787993,0.9705204],"study_design_scores_gemma":[0.002401256,0.0001769985,0.00002468367,0.00322312,0.0006881672,0.000299383,0.0001702234,0.00001047031,2.93421e-7,0.0001124852,0.9923838,0.0005090659],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000003552831,0.9876418,0.002031937,0.001763831,0.00518307,0.001345598,0.0007029392,0.00003563977,0.001291604],"genre_scores_gemma":[0.00004116087,0.9873616,0.0002947059,0.001334304,0.0002312493,0.0002405857,0.00104951,0.00009945878,0.009347466],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9700114,"threshold_uncertainty_score":0.9999356,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05261507159770797,"score_gpt":0.3408309752815692,"score_spread":0.2882159036838613,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}