{"id":"W2778421654","doi":"10.3390/v10010008","title":"RNA Interference Therapies for an HIV-1 Functional Cure","year":2017,"lang":"en","type":"review","venue":"Viruses","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Jewish General Hospital","funders":"Canadian Institutes of Health Research; McGill University","keywords":"RNA interference; RNA; DNA-directed RNA interference; Human immunodeficiency virus (HIV); Genetic enhancement; Biology; Drug; Viral replication; Computational biology; Gene; Virology; Medicine; Bioinformatics; Virus; Genetics; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001079656,0.0003332806,0.0005520902,0.00006251743,0.000154411,0.0001151355,0.0005815983,0.0003550719,0.00006865394],"category_scores_gemma":[0.00005292838,0.0002565124,0.0003686973,0.00002042376,0.00009420948,0.00001157568,0.0001180664,0.0001264012,0.0001081139],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001090235,"about_ca_system_score_gemma":0.0002127765,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001060597,"about_ca_topic_score_gemma":0.00003390387,"domain_scores_codex":[0.9988828,0.00005605282,0.0002719178,0.000497342,0.00007687182,0.0002149751],"domain_scores_gemma":[0.9988593,0.00002182468,0.0002539112,0.0006988255,0.0001019697,0.0000641998],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00005642089,0.00005412313,0.000008743996,0.001012904,0.0003238824,0.000001038227,0.00001572131,4.633781e-7,0.00207258,0.0000682788,0.03828583,0.9581],"study_design_scores_gemma":[0.0001092473,0.0004041701,0.000003398017,0.0009835475,0.000150133,0.00001115438,0.00001412351,9.210709e-7,0.001002939,0.00004674053,0.9969566,0.0003170108],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001566554,0.9969553,0.0009027065,0.00001075484,0.0005870753,0.0003386615,0.0005071007,0.0000158096,0.0005259835],"genre_scores_gemma":[0.0002996836,0.9945211,0.0001203002,0.000200337,0.001202748,0.0002164108,0.001031256,0.00004752773,0.002360678],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9586708,"threshold_uncertainty_score":0.9999887,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2419246953645125,"score_gpt":0.4071242397751266,"score_spread":0.1651995444106141,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}