{"id":"W2778533760","doi":"10.1139/bcb-2017-0262","title":"The <i>Drosophila</i> <i>hep</i> pathway mediates Lrrk2-induced neurodegeneration","year":2017,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Neurological diseases and metabolism","field":"Neuroscience","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; National Natural Science Foundation of China; American Parkinson Disease Association","keywords":"Neurodegeneration; Drosophila (subgenus); LRRK2; Biology; Cell biology; Genetics; Neuroscience; Mutation; Disease; Medicine; Gene; Pathology","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009866818,0.000148391,0.0001245108,0.000005814859,0.00110576,0.0001458985,0.0004437234,0.000132455,0.0000114356],"category_scores_gemma":[0.0005693889,0.0000921605,0.0000584118,0.00002372717,0.0003721211,0.00004972031,0.0001927371,0.0001500739,0.00001729403],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002599424,"about_ca_system_score_gemma":0.00002760261,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004741164,"about_ca_topic_score_gemma":6.839569e-7,"domain_scores_codex":[0.998955,0.00008313945,0.0001481519,0.0004629139,0.00007021323,0.0002806208],"domain_scores_gemma":[0.9990305,0.0001690209,0.0001465102,0.0005021392,0.00001839187,0.0001334015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002962286,0.00002922774,0.0001696547,0.000006526924,8.320856e-7,0.000007836325,0.000003602984,1.679939e-7,0.9929468,0.001574889,0.0001444396,0.00508641],"study_design_scores_gemma":[0.0002384149,0.00006025247,0.0006322218,0.000001125636,0.000006841808,0.000006565374,0.000003007776,0.0000293141,0.9587727,0.00148605,0.03865215,0.0001113163],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9880251,0.0007540974,0.000001874466,0.001773399,0.0005480369,0.00009371412,0.00004034225,0.00003593147,0.008727496],"genre_scores_gemma":[0.9956003,0.001578749,0.000004531835,0.001796758,0.000384325,0.00002216054,0.000007127454,0.000007790242,0.0005982215],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03850771,"threshold_uncertainty_score":0.8504722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02455660250903494,"score_gpt":0.2472759763142652,"score_spread":0.2227193738052302,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}