{"id":"W2778589312","doi":"10.1016/j.yjmcc.2017.12.014","title":"Serotonin receptor 2B signaling with interstitial cell activation and leaflet remodeling in degenerative mitral regurgitation","year":2017,"lang":"en","type":"article","venue":"Journal of Molecular and Cellular Cardiology","topic":"Cardiac Valve Diseases and Treatments","field":"Medicine","cited_by":47,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Ottawa","funders":"National Heart, Lung, and Blood Institute; National Institutes of Health","keywords":"Ventricular remodeling; Downregulation and upregulation; Angiotensin II; Medicine; Internal medicine; Receptor; Mitral valve prolapse; Heart failure; Endocrinology; Biology; Mitral valve","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002363633,0.0001991668,0.0002565895,0.0002096991,0.000202467,0.0003818468,0.0001728065,0.0004757375,0.001351419],"category_scores_gemma":[0.0002513183,0.0001705305,0.0002604438,0.0001454796,0.0003157727,0.000190162,0.0001950075,0.0004173187,0.0002446066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002192014,"about_ca_system_score_gemma":0.0001572246,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009293114,"about_ca_topic_score_gemma":0.001263591,"domain_scores_codex":[0.9998556,0.00004987199,0.00001355823,0.00001563147,0.0000217202,0.00004355528],"domain_scores_gemma":[0.9998797,0.00001934877,0.00004330376,0.000008063306,0.00001157871,0.00003798511],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.01113533,0.0003802367,0.06758824,0.000394005,0.0002687575,0.005079523,0.0005463424,0.0003834626,0.8918295,0.001251973,0.001420491,0.01972204],"study_design_scores_gemma":[0.0006619376,0.002513811,0.8909908,0.00009214601,0.0005883634,0.007657995,0.001436291,0.002706751,0.08786844,0.00110395,0.004337388,0.00004209813],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9931858,0.005190973,0.0004335757,0.0002770579,0.00003570619,0.00000629929,0.00009909405,0.000009926074,0.0007615791],"genre_scores_gemma":[0.9984717,0.0007020443,0.0001306145,0.00006105309,0.00002243977,0.000007169283,0.00007158356,0.000001558703,0.0005317997],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001351419,"threshold_uncertainty_score":0.004520953,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01183118540198808,"score_gpt":0.2834688920190091,"score_spread":0.271637706617021,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}