{"id":"W2778792629","doi":"10.1139/bcb-2017-0274","title":"Emerging branches of the N-end rule pathways are revealing the sequence complexities of N-termini dependent protein degradation","year":2017,"lang":"en","type":"article","venue":"Biochemistry and Cell Biology","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Protein degradation; Proteasome; Computational biology; Biochemistry; Amino acid; Protein sequencing; Peptide sequence; Ubiquitin; Biology; Protein stability; Chemistry; Cell biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006244694,0.0005756966,0.0005090184,0.0005829784,0.0002178959,0.001004515,0.0003385544,0.0004670034,0.0007782851],"category_scores_gemma":[0.0003978879,0.000145717,0.0004561282,0.0003354656,0.0007056359,0.001301978,0.000473689,0.001715931,0.0003809335],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004094574,"about_ca_system_score_gemma":0.0004613195,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001428726,"about_ca_topic_score_gemma":0.0002845418,"domain_scores_codex":[0.9996992,0.00005026313,0.00003211678,0.00005795141,0.0001263474,0.00003415776],"domain_scores_gemma":[0.9994889,0.0001545764,0.0001780434,0.0000465256,0.00007187248,0.00006009914],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007235018,0.0001741543,0.00273899,0.001083027,0.00007445458,0.0008690044,0.0001046407,0.0009632473,0.822504,0.01241512,0.0005549288,0.157795],"study_design_scores_gemma":[0.00002897979,0.001068374,0.008225362,0.0001303944,0.0000965911,0.003993369,0.0001015663,0.003224785,0.9177758,0.01228002,0.05302981,0.00004498282],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.389154,0.3898639,0.1786493,0.005142249,0.0006652753,0.0001697751,0.0004660262,0.0004533922,0.03543606],"genre_scores_gemma":[0.6728782,0.238233,0.07835864,0.00140479,0.0006844776,0.00008714409,0.0007024701,0.00006096596,0.007590326],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.001004515,"threshold_uncertainty_score":0.003302515,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04014813569076974,"score_gpt":0.2759743523351041,"score_spread":0.2358262166443344,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}