{"id":"W2778847088","doi":"10.1182/blood.v128.22.4281.4281","title":"Aside from the Allelic Burden of JAK2-V617F, Acquisition of Mutations in Myeloid Gene Panel Is Associated with the Transformation of Myeloproliferative Neoplasm into Secondary AML","year":2016,"lang":"en","type":"article","venue":"Blood","topic":"Myeloproliferative Neoplasms: Diagnosis and Treatment","field":"Medicine","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto","funders":"","keywords":"Myeloid; Myeloproliferative neoplasm; JAK2 V617F; Mutation; Gene; Biology; Allele; Genetics; Medicine; Cancer research; Oncology; Bone marrow; Immunology; Myelofibrosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001419921,0.0001739265,0.0001739991,0.0006803387,0.000252519,0.0002602624,0.0001236477,0.0001754639,0.002840422],"category_scores_gemma":[0.0004258318,0.00009154977,0.0001011907,0.0003896948,0.0001964387,0.0001107844,0.0001998907,0.00021537,0.0003007998],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001551756,"about_ca_system_score_gemma":0.000128426,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005012194,"about_ca_topic_score_gemma":0.0007995474,"domain_scores_codex":[0.9998016,0.00002139899,0.00002327619,0.00007134949,0.00004761439,0.00003489089],"domain_scores_gemma":[0.9996668,0.00006911293,0.0001340202,0.00002315377,0.00003702593,0.00006979357],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003077108,0.0000589421,0.8911075,0.00004600047,0.00005403025,0.002007916,0.0001026097,0.0001293663,0.09122513,0.00008597371,0.0003454569,0.01452933],"study_design_scores_gemma":[0.00001517489,0.0001341234,0.9637994,0.00001243464,0.00004938328,0.01507914,0.00008244409,0.0003884333,0.01917861,0.00009496869,0.001160751,0.000005093928],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9986387,0.0002649139,0.0002812442,0.00002413393,0.000002564979,0.000007368355,0.0002213836,0.000009100978,0.0005506277],"genre_scores_gemma":[0.9993338,0.000077904,0.0001851776,0.00001436791,0.000003666572,0.000004827507,0.0002226076,0.000002742309,0.0001548607],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002840422,"threshold_uncertainty_score":0.009502172,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0145459716774275,"score_gpt":0.237825839517576,"score_spread":0.2232798678401485,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}