{"id":"W2778853949","doi":"10.1172/jci.insight.96560","title":"Targeting and silencing of rhodopsin by ectopic expression of the transcription factor KLF15","year":2017,"lang":"en","type":"article","venue":"JCI Insight","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institute of Genetics; European Research Council; Fondazione Telethon","keywords":"Ectopic expression; Biology; Gene silencing; Transcription factor; Gene; Genetics; Gene expression; Retinitis pigmentosa; Cell biology; Regulation of gene expression","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002727105,0.0002535158,0.0002212351,0.0001810839,0.0001182983,0.0003047367,0.0003023478,0.0002613694,0.0007825983],"category_scores_gemma":[0.0001482857,0.0001455382,0.0003003637,0.00009432903,0.0002903092,0.0001714533,0.0003620104,0.0004142721,0.0004532961],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002629539,"about_ca_system_score_gemma":0.0002778089,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004628936,"about_ca_topic_score_gemma":0.0008490588,"domain_scores_codex":[0.9997963,0.00003039332,0.00003522967,0.00005159355,0.00005316378,0.00003327399],"domain_scores_gemma":[0.9998353,0.0000279506,0.00006601275,0.00002745003,0.00001213148,0.00003114011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001343728,0.000003677446,0.00009188189,0.00001203573,0.0000017216,0.00002376455,0.000005880634,0.00004083168,0.9991309,0.000154253,0.000006017322,0.0005156922],"study_design_scores_gemma":[0.000005309792,0.00004903555,0.0007274364,0.000003865477,0.000006693643,0.0001533717,0.00001129831,0.0005276026,0.9970995,0.00003461587,0.001378936,0.000002365196],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9649808,0.0009343877,0.03013831,0.0001295372,0.00004423906,0.0000604652,0.0004639566,0.0002517196,0.002996551],"genre_scores_gemma":[0.9867762,0.0004741672,0.009655353,0.00005608813,0.000005476077,0.00003118424,0.0003175343,0.00007189999,0.00261199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007825983,"threshold_uncertainty_score":0.002618074,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009673822414378856,"score_gpt":0.2686326152578916,"score_spread":0.2589587928435127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}