{"id":"W2779204423","doi":"10.1212/wnl.0000000000004853","title":"Genetic variation in <i>CFH</i> predicts phenytoin-induced maculopapular exanthema in European-descent patients","year":2017,"lang":"en","type":"article","venue":"Neurology","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Health and Medical Research Fund; Medical Research Council; Canadian Institutes of Health Research; Universitair Ziekenhuis Antwerpen; Epilepsy Society; Háskóli Íslands; Eisai; Università degli Studi di Genova; Eberhard Karls Universität Tübingen; Ministry of Education of the People's Republic of China; Fundação de Amparo à Pesquisa do Estado de São Paulo; Science Foundation Ireland; Novartis Pharma; European Commission; Stichting Epilepsie Instellingen Nederland; GlaxoSmithKline; Imperial College London; BC Children's Hospital; National Institute for Health and Care Research; University of Toronto; University College London; Li Ka Shing Faculty of Medicine, University of Hong Kong; Royal College of Surgeons in Ireland; UCB Pharma; Valeant Pharmaceuticals International; Universität Wien; Guangzhou Medical University; Philipps-Universität Marburg; Université du Luxembourg; Medizinische Universität Wien; Universitair Medisch Centrum Utrecht; Amgen; Pfizer; Rheinische Friedrich-Wilhelms-Universität Bonn; Universiteit Antwerpen; Canadian Dermatology Foundation","keywords":"Phenytoin; Variation (astronomy); Genetic variation; Medicine; Descent (aeronautics); Genetic variants; Genetics; Genotype; Biology; Gene; Epilepsy; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002119048,0.0001857918,0.0003039446,0.0002375182,0.0001007019,0.00002116638,0.0002188422,0.0001411746,0.00001531871],"category_scores_gemma":[0.0004550082,0.0001884649,0.0000545342,0.0001081612,0.00005434057,0.0001260561,0.0001318541,0.0005009074,0.0001817235],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008150424,"about_ca_system_score_gemma":0.00007248705,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003052691,"about_ca_topic_score_gemma":0.0002551055,"domain_scores_codex":[0.9982781,0.0002351006,0.0003904547,0.0004737107,0.0002226621,0.0003999553],"domain_scores_gemma":[0.9987921,0.00005214033,0.0002128056,0.0007579047,0.00006047537,0.0001246116],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0002187207,0.001450453,0.8803176,0.00004990011,0.00003377222,0.001938025,0.0005414619,0.00008905053,0.07535648,0.00008344151,0.00004673048,0.03987432],"study_design_scores_gemma":[0.003858787,0.0002312177,0.9928314,0.00003750385,0.00003295132,0.00007228404,0.000003260243,0.000410324,0.0003338313,0.00006759554,0.002000933,0.0001199088],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9751706,0.000008915246,0.00001894304,0.001128781,0.0007591119,0.0005682803,0.000004330261,0.00005062778,0.02229044],"genre_scores_gemma":[0.9985477,0.00003569185,0.0001026791,0.001016661,0.0001707592,0.00002337661,0.00001135891,0.00004750356,0.00004430583],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1125138,"threshold_uncertainty_score":0.7685375,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02191469383560869,"score_gpt":0.2611200847564468,"score_spread":0.2392053909208381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}