{"id":"W2779204423","doi":"10.1212/wnl.0000000000004853","title":"Genetic variation in <i>CFH</i> predicts phenytoin-induced maculopapular exanthema in European-descent patients","year":2017,"lang":"en","type":"article","venue":"Neurology","topic":"Drug-Induced Adverse Reactions","field":"Medicine","cited_by":40,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Health and Medical Research Fund; Medical Research Council; Canadian Institutes of Health Research; Universitair Ziekenhuis Antwerpen; Epilepsy Society; Háskóli Íslands; Eisai; Università degli Studi di Genova; Eberhard Karls Universität Tübingen; Ministry of Education of the People's Republic of China; Fundação de Amparo à Pesquisa do Estado de São Paulo; Science Foundation Ireland; Novartis Pharma; European Commission; Stichting Epilepsie Instellingen Nederland; GlaxoSmithKline; Imperial College London; BC Children's Hospital; National Institute for Health and Care Research; University of Toronto; University College London; Li Ka Shing Faculty of Medicine, University of Hong Kong; Royal College of Surgeons in Ireland; UCB Pharma; Valeant Pharmaceuticals International; Universität Wien; Guangzhou Medical University; Philipps-Universität Marburg; Université du Luxembourg; Medizinische Universität Wien; Universitair Medisch Centrum Utrecht; Amgen; Pfizer; Rheinische Friedrich-Wilhelms-Universität Bonn; Universiteit Antwerpen; Canadian Dermatology Foundation","keywords":"Phenytoin; Variation (astronomy); Genetic variation; Medicine; Descent (aeronautics); Genetic variants; Genetics; Genotype; Biology; Gene; Epilepsy; Psychiatry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000830468,0.0004353547,0.0003670079,0.0006879653,0.0003618459,0.0004336784,0.0003240115,0.0007568168,0.001790345],"category_scores_gemma":[0.001840621,0.0002367894,0.0008174867,0.0009326818,0.000338557,0.0002684242,0.000282737,0.000322293,0.0001727003],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001712649,"about_ca_system_score_gemma":0.0001837805,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003230944,"about_ca_topic_score_gemma":0.002226128,"domain_scores_codex":[0.9996291,0.0001259345,0.00004806529,0.0001204268,0.0000368458,0.00003960626],"domain_scores_gemma":[0.9991197,0.0003294717,0.0003067881,0.00009404657,0.00004723802,0.0001027304],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0004813578,0.00002322415,0.9956328,0.00001734181,0.0004169865,0.000236153,0.00003816513,0.00009161418,0.00140696,0.00003139875,0.00009799603,0.001525907],"study_design_scores_gemma":[0.00004508399,0.00009381679,0.9979703,0.000009284826,0.0002806799,0.0006128421,0.00005013808,0.0005092417,0.0002349787,0.00005939696,0.0001295929,0.000004784467],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9991774,0.0002951964,0.0001087921,0.00003885073,0.000004847025,0.000004838366,0.0001434456,0.000004096399,0.0002223871],"genre_scores_gemma":[0.9996469,0.00006543331,0.00007884233,0.00002495358,0.000009558169,0.000003097126,0.0001121227,0.000001747316,0.00005741178],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003230944,"threshold_uncertainty_score":0.006424248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02191469383560869,"score_gpt":0.2611200847564468,"score_spread":0.2392053909208381,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}