{"id":"W2779381970","doi":"10.1021/acs.chemrev.7b00120","title":"Proteolytic Cleavage—Mechanisms, Function, and “Omic” Approaches for a Near-Ubiquitous Posttranslational Modification","year":2017,"lang":"en","type":"review","venue":"Chemical Reviews","topic":"Peptidase Inhibition and Analysis","field":"Medicine","cited_by":228,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Institute of Musculoskeletal Health and Arthritis; Canadian Institutes of Health Research; Canada Research Chairs","keywords":"Proteases; Chemistry; Proteomics; Cleavage (geology); Protease; Biochemistry; Proteolytic enzymes; Proteolysis; Cell biology; Computational biology; Enzyme; Biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0005520124,0.000438665,0.0022327,0.00009726604,0.0001896527,0.0001031402,0.0001554192,0.0004324353,0.00006518315],"category_scores_gemma":[0.0005407034,0.0003229067,0.001019762,0.0001298957,0.0001472074,0.00008361589,0.00003676067,0.0003751814,0.0001201765],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009217868,"about_ca_system_score_gemma":0.0002436294,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000146876,"about_ca_topic_score_gemma":3.517398e-7,"domain_scores_codex":[0.9978266,0.00006301216,0.0009765067,0.0006702169,0.0002120107,0.0002516194],"domain_scores_gemma":[0.9982771,0.00009518688,0.0006752709,0.0006352905,0.00008152718,0.0002355978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00002606651,0.00008678083,2.161584e-7,0.03361697,0.000119026,0.000001040591,0.00000907611,2.178498e-8,0.0002038051,0.0008275246,0.002990984,0.9621185],"study_design_scores_gemma":[0.0004533382,0.00005414845,0.000001019359,0.02135808,0.002637387,0.00007134115,0.000001931873,0.0001821934,0.00007273792,0.001161947,0.9737089,0.0002970146],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000002641834,0.9853711,0.009260704,0.0004974109,0.00002900955,0.004199645,0.00007500238,0.00004907996,0.0005153828],"genre_scores_gemma":[0.00004269778,0.9897912,0.004608842,0.0002619235,0.0003896522,0.001876611,0.002077157,0.00005994557,0.0008919955],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9707178,"threshold_uncertainty_score":0.9999223,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3798369348253872,"score_gpt":0.4142308508789491,"score_spread":0.03439391605356185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}