{"id":"W2779386198","doi":"10.1007/s00213-017-4814-3","title":"Characterizing the subjective, observer-rated, and physiological effects of hydromorphone relative to heroin in a human laboratory study","year":2017,"lang":"en","type":"article","venue":"Psychopharmacology","topic":"Opioid Use Disorder Treatment","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"NOSM University; University of Toronto; Centre for Addiction and Mental Health; Health Canada","funders":"Open Society Institute; National Institute on Drug Abuse; Abell Foundation","keywords":"Hydromorphone; Heroin; Placebo; Opioid; Pharmacology; Medicine; Anesthesia; Morphine; Potency; Psychology; Drug; Internal medicine; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006511897,0.0004522872,0.0002774553,0.0001909542,0.0002742679,0.0004361165,0.0001927745,0.0002781306,0.001326624],"category_scores_gemma":[0.002056607,0.0001746254,0.0001964949,0.0001454291,0.0009014901,0.000235728,0.000237426,0.0005759378,0.0001663304],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001781848,"about_ca_system_score_gemma":0.00035826,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009888051,"about_ca_topic_score_gemma":0.00193701,"domain_scores_codex":[0.9994817,0.0002350203,0.00002519178,0.00009834681,0.0001169568,0.000042807],"domain_scores_gemma":[0.99893,0.0004002831,0.0002423335,0.0001565055,0.00009894014,0.0001718903],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0330346,0.004250026,0.04032889,0.0002741717,0.0002449719,0.0003168764,0.001357661,0.0004762966,0.9024892,0.0001899378,0.0003097081,0.01672758],"study_design_scores_gemma":[0.0008053632,0.09282566,0.6939135,0.00002410533,0.0003853771,0.001404097,0.001628598,0.003285988,0.203687,0.0001569477,0.001809788,0.00007357857],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9976963,0.0001393408,0.00140276,0.00001315956,0.00002010158,0.00007810571,0.0001286749,0.000008721854,0.0005128842],"genre_scores_gemma":[0.9971084,0.0001806229,0.001758509,0.00003395322,0.00002548521,0.00008629631,0.0001609826,0.00001182772,0.0006339112],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001326624,"threshold_uncertainty_score":0.004437983,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02885327276034188,"score_gpt":0.3599616950543415,"score_spread":0.3311084222939996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}