{"id":"W2779488239","doi":"10.1177/1849543517746259","title":"Cytotoxicity assessment, inflammatory properties, and cellular uptake of Neutraplex lipid-based nanoparticles in THP-1 monocyte-derived macrophages","year":2017,"lang":"en","type":"article","venue":"Nanobiomedicine","topic":"HIV Research and Treatment","field":"Immunology and Microbiology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institut National de la Recherche Scientifique; Health Canada; Public Health Agency of Canada","funders":"","keywords":"Small interfering RNA; Cytotoxicity; THP1 cell line; Endosome; Monocyte; Macrophage; In vitro; Drug delivery; Cell biology; Lysosome; Cell culture; Chemistry; Small hairpin RNA; Biology; Cell; Transfection; Gene knockdown; Biochemistry; Immunology; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004042897,0.0002011545,0.0004205488,0.000187492,0.0002715963,0.00002297462,0.0002814122,0.0001627414,0.0001629874],"category_scores_gemma":[0.00009011393,0.0001448324,0.00004885169,0.00007980735,0.001036534,0.0001095587,0.0001180957,0.0002149795,0.00004481176],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005964635,"about_ca_system_score_gemma":0.0002017677,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005335203,"about_ca_topic_score_gemma":0.0001926692,"domain_scores_codex":[0.9986387,0.0001451752,0.0003920915,0.0003141438,0.00008232471,0.0004275446],"domain_scores_gemma":[0.9990836,0.00005846146,0.0001936399,0.0005337317,0.00006421575,0.00006635309],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002762827,0.0002774113,0.05858344,0.0001079089,0.00008936064,0.00008209533,0.0001510398,0.000001327273,0.9355336,0.00003188254,0.000115839,0.004749771],"study_design_scores_gemma":[0.004368013,0.0004382216,0.2995517,0.0001161308,0.00002215493,0.000005435318,0.00006648335,0.00001717188,0.6942056,0.00001027928,0.001107169,0.00009156682],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9953018,0.00308089,0.00001543091,0.0006473825,0.0001458233,0.0005112318,0.00005601296,0.00003055542,0.0002109181],"genre_scores_gemma":[0.9992303,0.0001832763,0.0001039587,0.00004252117,0.0000280406,0.00006340067,0.00006444241,0.00001611584,0.0002679381],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.241328,"threshold_uncertainty_score":0.5906092,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03425278021723687,"score_gpt":0.2818761326540816,"score_spread":0.2476233524368447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}