{"id":"W2779647684","doi":"10.1111/adb.12590","title":"Rat brain<scp>CYP2D</scp>activity alters<i>in vivo</i>central oxycodone metabolism, levels and resulting analgesia","year":2017,"lang":"en","type":"article","venue":"Addiction Biology","topic":"Pain Management and Opioid Use","field":"Medicine","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"Campbell Family Mental Health Research Institute; National Institute on Drug Abuse; Ontario Ministry of Research, Innovation and Science; Canada Foundation for Innovation; Canadian Institutes of Health Research; Ontario Ministry of Research and Innovation; Centre for Addiction and Mental Health Foundation","keywords":"Oxycodone; In vivo; Pharmacology; Metabolism; Neuroscience; Medicine; Anesthesia; Opioid; Biology; Endocrinology; Internal medicine; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002503464,0.0007409687,0.0004742553,0.0004061089,0.0002969798,0.0004334722,0.0003256456,0.0004551185,0.002607737],"category_scores_gemma":[0.0001907928,0.0002747508,0.0005496787,0.000384391,0.0007511678,0.0003711575,0.0001458478,0.001393352,0.0007178164],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008093937,"about_ca_system_score_gemma":0.0006402654,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004538822,"about_ca_topic_score_gemma":0.006060821,"domain_scores_codex":[0.9996964,0.00004225099,0.00002850941,0.00007113057,0.00006910482,0.0000926242],"domain_scores_gemma":[0.9997262,0.00005417665,0.00006820029,0.00004773032,0.00004498291,0.00005871775],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007193555,0.0001184535,0.0002053106,0.00003692516,0.00001630342,0.0000359827,0.00001364689,0.00008676831,0.9975056,0.0001018617,0.000145852,0.001014003],"study_design_scores_gemma":[0.00003707806,0.0006224642,0.001789857,0.000003183444,0.00002733767,0.00008674133,0.00001846111,0.0005735546,0.9960283,0.00002401618,0.0007845733,0.000004547799],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9864608,0.001122076,0.006968413,0.0003916824,0.0001275005,0.000115819,0.001980645,0.0003572664,0.002475847],"genre_scores_gemma":[0.9803423,0.001061591,0.007485726,0.0001904952,0.00004731533,0.0002584572,0.003563002,0.0001521056,0.006898969],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004538822,"threshold_uncertainty_score":0.009024858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02755743105144926,"score_gpt":0.2968633211635991,"score_spread":0.2693058901121498,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}