{"id":"W2780240470","doi":"10.1093/cid/cix1108","title":"Effectiveness of Protease Inhibitor/Nucleos(t)ide Reverse Transcriptase Inhibitor–Based Second-line Antiretroviral Therapy for the Treatment of Human Immunodeficiency Virus Type 1 Infection in Sub-Saharan Africa: A Systematic Review and Meta-analysis","year":2017,"lang":"en","type":"article","venue":"Clinical Infectious Diseases","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Institute of Infection and Immunity","funders":"National Institute of Allergy and Infectious Diseases; National Institutes of Health; Wellcome; Medical Research Council; National Institute for Health and Care Research; Wellcome Trust","keywords":"Reverse transcriptase; Protease; Antiretroviral therapy; Human immunodeficiency virus (HIV); Protease inhibitor (pharmacology); Lentivirus; Viral disease","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001213695,0.0003604246,0.002924855,0.00028486,0.0002822039,0.00003703871,0.000111128,0.0001147266,0.00006367511],"category_scores_gemma":[0.0007983703,0.0002073881,0.001785529,0.0004655441,0.0003594389,0.0001291173,0.00001885035,0.0001128502,0.000002977737],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001117547,"about_ca_system_score_gemma":0.0001684595,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002093656,"about_ca_topic_score_gemma":0.0001106391,"domain_scores_codex":[0.9970757,0.0006704036,0.001315786,0.0004690165,0.0002400828,0.0002290254],"domain_scores_gemma":[0.9969079,0.0009858026,0.0008053294,0.0008821195,0.0002829857,0.0001358314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"meta_analysis","study_design_scores_codex":[0.004092783,0.03497582,0.6229303,0.1884665,0.1409952,0.00008505456,0.0003395478,0.00003610328,0.006863727,0.00007633545,0.0003051425,0.0008334578],"study_design_scores_gemma":[0.01664689,0.01285964,0.3507572,0.004961215,0.6018877,0.000003814731,0.00001790324,0.0001658044,0.01190647,0.0001057418,0.0001657341,0.0005219182],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9118317,0.07983513,0.00004674668,0.0001522199,0.00009945907,0.007706433,0.0002705264,0.00003718262,0.00002063263],"genre_scores_gemma":[0.9867649,0.0114643,0.0000108584,0.00005711593,0.00002601008,0.001417655,0.00008884776,0.00002683548,0.0001434507],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4608925,"threshold_uncertainty_score":0.845704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08633466016572307,"score_gpt":0.3796961659347159,"score_spread":0.2933615057689928,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}