{"id":"W2780263958","doi":"10.1111/ctr.13180","title":"Randomized open‐label crossover assessment of Prograf vs Advagraf on immunosuppressant pharmacokinetics and pharmacodynamics in simultaneous pancreas‐kidney patients","year":2017,"lang":"en","type":"article","venue":"Clinical Transplantation","topic":"Renal Transplantation Outcomes and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; University of Toronto","funders":"Astellas Pharma","keywords":"Medicine; Tacrolimus; Mycophenolic acid; Pharmacokinetics; Pharmacodynamics; Crossover study; Urology; Anesthesia; Pharmacology; Surgery; Transplantation; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007167134,0.0002596499,0.001025134,0.00008948798,0.0001539413,0.0001002644,0.0002474617,0.0001384975,0.00004445408],"category_scores_gemma":[0.0003647542,0.0001970036,0.0001605343,0.00006120805,0.0003493353,0.0002231128,0.00003030776,0.0003183535,0.000004434373],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003471592,"about_ca_system_score_gemma":0.0000968746,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009551835,"about_ca_topic_score_gemma":0.000009796955,"domain_scores_codex":[0.9975432,0.0002642547,0.001149639,0.000427707,0.0003753915,0.0002398647],"domain_scores_gemma":[0.9971361,0.001596476,0.0005359567,0.0003399198,0.000153982,0.0002375753],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.2864472,0.005668567,0.6891371,0.001358317,0.0008119564,0.0003651543,0.0002666954,0.0002299252,0.0005410835,0.0004599211,0.00001137932,0.01470269],"study_design_scores_gemma":[0.5603917,0.001010529,0.4177033,0.001220981,0.001114999,0.0000119667,0.00000611168,0.01746748,0.0007026479,0.0001045606,0.00006397572,0.0002017568],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9935579,0.00003958251,0.0004473967,0.0003064916,0.0003797653,0.002555778,0.0004060406,0.00002172011,0.002285332],"genre_scores_gemma":[0.9878547,0.007346599,0.003368827,0.0004627679,0.00003470274,0.00009061619,0.0006628261,0.00002859317,0.0001503945],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2739445,"threshold_uncertainty_score":0.8033572,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06476060423009623,"score_gpt":0.4684073455709999,"score_spread":0.4036467413409037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}