{"id":"W2780330613","doi":"10.1016/j.devcel.2017.12.008","title":"Linking Hedgehog, Translation, and mTORC1 in Medulloblastoma","year":2017,"lang":"en","type":"letter","venue":"Developmental Cell","topic":"Hedgehog Signaling Pathway Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"McGill University; Université de Montréal; Montreal Clinical Research Institute","funders":"","keywords":"Biology; Medulloblastoma; Translation (biology); Hedgehog; mTORC1; Hedgehog signaling pathway; Computational biology; Cell biology; Genetics; Signal transduction; PI3K/AKT/mTOR pathway; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.000175646,0.0003439627,0.0002963947,0.0001053298,0.0001761879,0.00006105415,0.000288011,0.0006861076,0.00001404175],"category_scores_gemma":[0.0000250296,0.0003637753,0.00006375574,0.00003909559,0.0001324389,0.000004208217,0.000177199,0.0005011786,0.00003450941],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004585724,"about_ca_system_score_gemma":0.0001772739,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001704652,"about_ca_topic_score_gemma":0.00008682367,"domain_scores_codex":[0.9984931,0.00005329126,0.0003039098,0.0005942481,0.0001869991,0.0003684647],"domain_scores_gemma":[0.9995217,0.00002165141,0.0001314771,0.000242377,0.00003869479,0.00004415567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00006730038,0.00007111023,0.02062953,0.001043802,0.0002119749,0.0009005937,0.002146333,0.000006711272,0.190801,0.000001211129,0.7679728,0.01614765],"study_design_scores_gemma":[0.0005353763,0.00004945489,0.001146702,0.0001403526,0.00001391973,0.00003511015,0.00004545685,0.000003492956,0.04474734,0.00001714444,0.9527708,0.0004949054],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8233209,0.02691395,0.0005640535,0.07394228,0.002161171,0.00191917,0.0002707479,0.0001254955,0.07078218],"genre_scores_gemma":[0.7591428,0.001646936,0.01025518,0.1982542,0.00559161,0.000226475,0.004671872,0.0003812459,0.0198297],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.184798,"threshold_uncertainty_score":0.9998814,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02329925766182428,"score_gpt":0.2366828218016429,"score_spread":0.2133835641398186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}