{"id":"W2780549108","doi":"10.1016/j.bbamcr.2017.12.007","title":"The putative flippase Apt1 is required for intracellular membrane architecture and biosynthesis of polysaccharide and lipids in Cryptococcus neoformans","year":2017,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health; Fogarty International Center; National Heart, Lung, and Blood Institute; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico; U.S. Department of Veterans Affairs","keywords":"Flippase; Biochemistry; Cryptococcus neoformans; Intracellular; Biology; Phosphatidylserine; Vesicle; Polysaccharide; Vacuole; Cell biology; Chemistry; Microbiology; Membrane; Cytoplasm","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001132246,0.0002629781,0.0004667847,0.0002936004,0.0009510971,0.0001772539,0.0002977875,0.0001503053,0.000005953851],"category_scores_gemma":[0.000704679,0.000184482,0.0001566283,0.0002495613,0.001246446,0.00009984733,0.0003142281,0.000579898,0.000002976305],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004294079,"about_ca_system_score_gemma":0.0001382936,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002935345,"about_ca_topic_score_gemma":0.00002992425,"domain_scores_codex":[0.9978633,0.0002382828,0.0003539792,0.0005127231,0.0004412807,0.0005904198],"domain_scores_gemma":[0.9978248,0.0007901244,0.0001688539,0.000772537,0.000264774,0.0001788926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006876908,0.000195953,0.00002761969,0.0003369896,0.0001576849,0.00002316366,0.001610938,7.480446e-7,0.9929066,0.0003372274,0.0001875367,0.003527811],"study_design_scores_gemma":[0.001242711,0.0007860971,0.001787322,0.0001406721,0.00008095258,0.000007714667,0.0006190586,0.0005192521,0.9929976,0.0008691681,0.0007676156,0.0001818355],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858071,0.0007039554,0.0001191326,0.01078486,0.00004882323,0.001455231,0.00008335196,0.00001560254,0.0009819841],"genre_scores_gemma":[0.9968076,0.001815695,0.0006760001,0.0001061632,0.00007497104,0.0001728426,0.000009557682,0.00004098646,0.0002961573],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01100057,"threshold_uncertainty_score":0.7522958,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03927738164004611,"score_gpt":0.3537184366452971,"score_spread":0.3144410550052509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}