{"id":"W2780549108","doi":"10.1016/j.bbamcr.2017.12.007","title":"The putative flippase Apt1 is required for intracellular membrane architecture and biosynthesis of polysaccharide and lipids in Cryptococcus neoformans","year":2017,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Molecular Cell Research","topic":"Fungal Infections and Studies","field":"Medicine","cited_by":35,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada's Michael Smith Genome Sciences Centre; University of British Columbia","funders":"National Institute of Allergy and Infectious Diseases; National Cancer Institute; National Institutes of Health; Fogarty International Center; National Heart, Lung, and Blood Institute; Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro; Conselho Nacional de Desenvolvimento Científico e Tecnológico; U.S. Department of Veterans Affairs","keywords":"Flippase; Biochemistry; Cryptococcus neoformans; Intracellular; Biology; Phosphatidylserine; Vesicle; Polysaccharide; Vacuole; Cell biology; Chemistry; Microbiology; Membrane; Cytoplasm","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007734484,0.000383127,0.0002636221,0.0002859066,0.0002138221,0.0003881347,0.0001665389,0.0002949625,0.0007309417],"category_scores_gemma":[0.0002629957,0.0001756161,0.0002322057,0.0002271155,0.0002383605,0.0002483866,0.0003197652,0.0004891234,0.0004316348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005109709,"about_ca_system_score_gemma":0.0003267842,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003323788,"about_ca_topic_score_gemma":0.002570417,"domain_scores_codex":[0.9998914,0.00001007625,0.00001026323,0.00001685351,0.00003673122,0.00003475245],"domain_scores_gemma":[0.9997879,0.00003748968,0.00007472961,0.0000214042,0.00003326965,0.00004528078],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001158203,0.0000105708,0.0005580944,0.00001986417,0.000001917224,0.0001794468,0.00001430798,0.00009084197,0.9981076,0.00006750383,0.00002198577,0.0008120562],"study_design_scores_gemma":[0.00001481156,0.0001239394,0.02795752,0.000008317302,0.00001958209,0.001290964,0.0001403035,0.002246839,0.966958,0.0001474948,0.001079239,0.00001315028],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9982603,0.0001684904,0.0007648224,0.00005501073,0.000011429,0.000006802658,0.0003112338,0.00003431951,0.0003876486],"genre_scores_gemma":[0.9982582,0.00006024134,0.0005766473,0.00002192852,0.000002349557,0.00000553583,0.0003931118,0.000009144291,0.0006728388],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003323788,"threshold_uncertainty_score":0.006608903,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03927738164004611,"score_gpt":0.3537184366452971,"score_spread":0.3144410550052509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}