{"id":"W2780667489","doi":"10.1038/s41588-017-0011-x","title":"Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity","year":2017,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Diet and metabolism studies","field":"Medicine","cited_by":428,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; Université de Montréal; Dalhousie University; Montreal Heart Institute","funders":"FP7 Ideas: European Research Council; Carolina Population Center, University of North Carolina at Chapel Hill; National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Center for Research Resources; National Institute of General Medical Sciences; National Human Genome Research Institute; National Institute on Drug Abuse; National Institute on Aging; National Institute of Diabetes and Digestive and Kidney Diseases; Norwegian Institute of Public Health; Danish Agency for Science and Higher Education; National Health and Medical Research Council; National Heart, Lung, and Blood Institute; Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Forsknings- og Innovationsstyrelsen; Directorate for Biological Sciences; National Institutes of Health; Diabetesforeningen; MRC-PHE Centre for Environment and Health; Centre for Cognitive Ageing and Cognitive Epidemiology; H. Lundbeck A/S; Hjartavernd; Institut de Cardiologie de Montréal; Fondation Institut de Cardiologie de Montréal; Medical Research Council; Servier; Regione Lombardia; Boehringer Ingelheim Stiftung; National Center for Advancing Translational Sciences; Economic and Social Research Council; Università degli Studi di Verona; Fondation Leenaards; A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene Formaal; Sydäntutkimussäätiö; Universitetet i Bergen; Aarhus Universitets Forskningsfond; Max-Planck-Gesellschaft; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Ministero della Salute; Region Hovedstaden; European Hematology Association; Novo Nordisk; British Heart Foundation; Bundesministerium für Bildung und Forschung; Strategiske Forskningsråd; ZonMw; SystemsX.ch; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; European Foundation for the Study of Diabetes; Cancer Research UK; National University of Singapore; Imperial College Healthcare NHS Trust; Wellcome Trust; Aarhus Universitet; Australian Government; Norges Forskningsråd; QIMR Berghofer Medical Research Institute; AstraZeneca; National Institute for Health Research Health Protection Research Unit; European Commission; Steno Diabetes Center Copenhagen; Norges Teknisk-Naturvitenskapelige Universitet; Wake Forest School of Medicine; Helse Vest; Johns Hopkins University; Sundhed og Sygdom, Det Frie Forskningsråd; National Cancer Institute; Lundbeckfonden; Foundation for Cardiovascular Research; Queen Mary University of London; National Institute for Health and Care Research; National Science Foundation; Massachusetts General Hospital; Istituto Superiore di Sanità; Imperial College London; Eunice Kennedy Shriver National Institute of Child Health and Human Development; GlaxoSmithKline; Erasmus Medisch Centrum; Andrea and Charles Bronfman Philanthropies; Novo Nordisk Fonden; American Heart Association; Diabetesforbundet; Pfizer","keywords":"Biology; Body mass index; Obesity; Energy expenditure; Genetics; Energy metabolism; Endocrinology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006542965,0.0006036093,0.000696694,0.001154937,0.0004469966,0.000759849,0.0003312613,0.0005794543,0.002977594],"category_scores_gemma":[0.001535596,0.0002236167,0.001357823,0.00193765,0.0004898536,0.0002504861,0.0005479716,0.00081777,0.0002303907],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002171387,"about_ca_system_score_gemma":0.000230559,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003160452,"about_ca_topic_score_gemma":0.004202927,"domain_scores_codex":[0.9994026,0.0001199903,0.00005820041,0.0002469359,0.0001140711,0.00005812221],"domain_scores_gemma":[0.9991966,0.0003777072,0.0002388696,0.00008697436,0.00004361894,0.00005634815],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.004628085,0.000122637,0.8445641,0.0009124649,0.01804469,0.002540969,0.0002902911,0.00201694,0.07326398,0.001198205,0.001472128,0.05094555],"study_design_scores_gemma":[0.00009526189,0.0001185992,0.985478,0.00008507414,0.004330468,0.001529343,0.00008592573,0.001238634,0.002813559,0.001570996,0.002632999,0.00002111109],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9661154,0.02147829,0.006212196,0.0007413918,0.000110463,0.00003345773,0.003341492,0.0001415694,0.00182579],"genre_scores_gemma":[0.9934076,0.002911985,0.001587423,0.0002377073,0.00005508324,0.0000184059,0.001341378,0.00003250578,0.0004077999],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003160452,"threshold_uncertainty_score":0.009961009,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01408586533173332,"score_gpt":0.2496970572586187,"score_spread":0.2356111919268853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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