{"id":"W2780667489","doi":"10.1038/s41588-017-0011-x","title":"Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity","year":2017,"lang":"en","type":"article","venue":"Nature Genetics","topic":"Diet and metabolism studies","field":"Medicine","cited_by":428,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University; Université de Montréal; Dalhousie University; Montreal Heart Institute","funders":"FP7 Ideas: European Research Council; Carolina Population Center, University of North Carolina at Chapel Hill; National Institute of Child Health and Human Development; National Institute of Environmental Health Sciences; National Institute of Neurological Disorders and Stroke; National Center for Research Resources; National Institute of General Medical Sciences; National Human Genome Research Institute; National Institute on Drug Abuse; National Institute on Aging; National Institute of Diabetes and Digestive and Kidney Diseases; Norwegian Institute of Public Health; Danish Agency for Science and Higher Education; National Health and Medical Research Council; National Heart, Lung, and Blood Institute; Biotechnology and Biological Sciences Research Council; Canadian Institutes of Health Research; Forsknings- og Innovationsstyrelsen; Directorate for Biological Sciences; National Institutes of Health; Diabetesforeningen; MRC-PHE Centre for Environment and Health; Centre for Cognitive Ageing and Cognitive Epidemiology; H. Lundbeck A/S; Hjartavernd; Institut de Cardiologie de Montréal; Fondation Institut de Cardiologie de Montréal; Medical Research Council; Servier; Regione Lombardia; Boehringer Ingelheim Stiftung; National Center for Advancing Translational Sciences; Economic and Social Research Council; Università degli Studi di Verona; Fondation Leenaards; A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene Formaal; Sydäntutkimussäätiö; Universitetet i Bergen; Aarhus Universitets Forskningsfond; Max-Planck-Gesellschaft; Deutsche Forschungsgemeinschaft; Nederlandse Organisatie voor Wetenschappelijk Onderzoek; Ministero della Salute; Region Hovedstaden; European Hematology Association; Novo Nordisk; British Heart Foundation; Bundesministerium für Bildung und Forschung; Strategiske Forskningsråd; ZonMw; SystemsX.ch; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; European Foundation for the Study of Diabetes; Cancer Research UK; National University of Singapore; Imperial College Healthcare NHS Trust; Wellcome Trust; Aarhus Universitet; Australian Government; Norges Forskningsråd; QIMR Berghofer Medical Research Institute; AstraZeneca; National Institute for Health Research Health Protection Research Unit; European Commission; Steno Diabetes Center Copenhagen; Norges Teknisk-Naturvitenskapelige Universitet; Wake Forest School of Medicine; Helse Vest; Johns Hopkins University; Sundhed og Sygdom, Det Frie Forskningsråd; National Cancer Institute; Lundbeckfonden; Foundation for Cardiovascular Research; Queen Mary University of London; National Institute for Health and Care Research; National Science Foundation; Massachusetts General Hospital; Istituto Superiore di Sanità; Imperial College London; Eunice Kennedy Shriver National Institute of Child Health and Human Development; GlaxoSmithKline; Erasmus Medisch Centrum; Andrea and Charles Bronfman Philanthropies; Novo Nordisk Fonden; American Heart Association; Diabetesforbundet; Pfizer","keywords":"Biology; Body mass index; Obesity; Energy expenditure; Genetics; Energy metabolism; Endocrinology; Internal medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001764452,0.0002336537,0.0004656625,0.00007275675,0.0001995838,0.00007093867,0.0001691849,0.000399791,0.000005971156],"category_scores_gemma":[0.0001348137,0.0001736538,0.000039072,0.00004965921,0.0001008449,0.00006206394,0.0001051967,0.0005509101,9.60852e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003817562,"about_ca_system_score_gemma":0.00005814905,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003608916,"about_ca_topic_score_gemma":0.0002260257,"domain_scores_codex":[0.9988393,0.000034111,0.0001600788,0.0003419694,0.0002729863,0.000351617],"domain_scores_gemma":[0.9991151,0.000022092,0.0001930349,0.0004550411,0.00009152089,0.000123178],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003706033,0.0001619329,0.95783,0.00005878036,0.0002692446,0.0002146627,0.0003223405,0.000002993466,0.03411725,0.0003359156,0.0001930069,0.00612328],"study_design_scores_gemma":[0.003871306,0.0001404311,0.9872406,0.0001759931,0.0001017641,0.000008505674,0.0000611768,0.0001471633,0.005086707,0.0006081117,0.002361358,0.000196954],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.994034,0.003048424,0.0002124466,0.0003527842,0.000227981,0.0004542005,0.00004299146,0.00003786634,0.001589306],"genre_scores_gemma":[0.9984385,0.0004287006,0.0002914426,0.0003325086,0.0002191536,0.00005049632,0.00001531326,0.00003008866,0.0001938303],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02941054,"threshold_uncertainty_score":0.7081396,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01408586533173332,"score_gpt":0.2496970572586187,"score_spread":0.2356111919268853,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). 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