{"id":"W2780727857","doi":"10.1016/j.virol.2017.12.023","title":"The OC43 human coronavirus envelope protein is critical for infectious virus production and propagation in neuronal cells and is a determinant of neurovirulence and CNS pathology","year":2017,"lang":"en","type":"article","venue":"Virology","topic":"SARS-CoV-2 and COVID-19 Research","field":"Medicine","cited_by":59,"is_retracted":false,"has_abstract":false,"ca_institutions":"Armand Frappier Museum; Institut National de la Recherche Scientifique","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Biology; Coronavirus; Virology; Transmembrane protein; Virulence; Virus; Viral envelope; Coronaviridae; Recombinant DNA; PDZ domain; Viral replication; Cell culture; Cell biology; Gene; Genetics; Coronavirus disease 2019 (COVID-19); Infectious disease (medical specialty); Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003899707,0.000110086,0.0002257144,0.0000885499,0.0003337558,0.00003134114,0.00007968018,0.0001190034,0.000001432092],"category_scores_gemma":[0.0008423827,0.00008250423,0.00001904892,0.00003365024,0.001111273,0.00008996156,0.0001227641,0.0002071318,0.000001359601],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001339445,"about_ca_system_score_gemma":0.00006344773,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000166076,"about_ca_topic_score_gemma":0.0003655021,"domain_scores_codex":[0.9989443,0.000108611,0.0002162285,0.0003808242,0.000103223,0.0002467826],"domain_scores_gemma":[0.9993667,0.0001557673,0.00009163639,0.0002763206,0.00008137808,0.00002817422],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0004754728,0.00007500577,0.04531583,0.0001547367,0.000005430264,0.00004768465,0.0003022077,1.600516e-8,0.9328176,0.0002503943,0.00001381323,0.02054182],"study_design_scores_gemma":[0.001141044,0.002401948,0.5036068,0.00003276977,0.00002866443,0.0003682777,0.00002098895,0.000284272,0.487658,0.001438847,0.002927021,0.0000914175],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964301,0.0001722676,0.00004657837,0.002238366,0.00007242401,0.0009744357,0.00001045377,0.000008600463,0.00004678518],"genre_scores_gemma":[0.9966579,0.00004729639,0.0000482845,0.002981521,0.00005721019,0.000173467,3.650182e-7,0.00001242088,0.00002153867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.458291,"threshold_uncertainty_score":0.4094532,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04902659149236044,"score_gpt":0.3722991829716641,"score_spread":0.3232725914793037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}