{"id":"W2780727948","doi":"10.1158/1078-0432.ccr-17-2994","title":"Genomics-Driven Precision Medicine for Advanced Pancreatic Cancer: Early Results from the COMPASS Trial","year":2017,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Pancreatic and Hepatic Oncology Research","field":"Medicine","cited_by":636,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Ontario Institute for Cancer Research; University of Toronto; University Health Network; BC Cancer Agency; Princess Margaret Cancer Centre","funders":"Canadian Cancer Society Research Institute; National Cancer Institute; Canadian Friends of Tel Aviv University; Ontario Institute for Cancer Research; Division of Cancer Prevention, National Cancer Institute","keywords":"Pancreatic cancer; Transcriptome; Medicine; Clinical endpoint; Oncology; FOLFIRINOX; Biopsy; Cancer; Precision medicine; Internal medicine; Biology; Pathology; Gene; Clinical trial; Gene expression; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001602875,0.0005074687,0.0005194267,0.0001500205,0.0001244656,0.0007880601,0.0001902598,0.0003302323,0.002665466],"category_scores_gemma":[0.001413121,0.00006809909,0.0005169247,0.0002942185,0.0004035692,0.000307281,0.0003533301,0.0005875094,0.0002343614],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007390298,"about_ca_system_score_gemma":0.0008075793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006245126,"about_ca_topic_score_gemma":0.001102832,"domain_scores_codex":[0.9994106,0.0004099771,0.00001311298,0.00006185197,0.00006079904,0.00004366371],"domain_scores_gemma":[0.9993086,0.0002205418,0.0001421171,0.00006333952,0.00006840776,0.0001970757],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.5113462,0.003251251,0.08301807,0.001451974,0.00599768,0.0004363353,0.0002786315,0.005519439,0.01896494,0.003261538,0.01902146,0.3474525],"study_design_scores_gemma":[0.3326954,0.1566128,0.3620309,0.001299804,0.009830845,0.001624684,0.0007728941,0.00968835,0.02443261,0.008967631,0.09182359,0.000220473],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9719923,0.01584817,0.001159231,0.004906397,0.0002751277,0.0001604811,0.001202757,0.00006826373,0.004387283],"genre_scores_gemma":[0.9899143,0.003434756,0.001218212,0.001884836,0.0004157567,0.0001353367,0.001461824,0.00001743307,0.001517516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002665466,"threshold_uncertainty_score":0.008916855,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4546718383273811,"score_gpt":0.6054100502091737,"score_spread":0.1507382118817926,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}