{"id":"W2780912000","doi":"10.1186/s13567-017-0495-5","title":"Detection of PrPBSE and prion infectivity in the ileal Peyer’s patch of young calves as early as 2 months after oral challenge with classical bovine spongiform encephalopathy","year":2017,"lang":"en","type":"article","venue":"Veterinary Research","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Canadian Food Inspection Agency","keywords":"Bovine spongiform encephalopathy; Infectivity; Biology; Virology; Bioassay; Immunohistochemistry; Pathogenesis; Genetically modified mouse; Transgene; Prion protein; Immunology; Pathology; Disease; Medicine; Virus; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008259031,0.0001018245,0.0001360033,0.00006632929,0.0001443938,0.00004457293,0.000228616,0.0001084804,0.000009875595],"category_scores_gemma":[0.0001843654,0.0000718665,0.00004581942,0.00006170619,0.0003250138,0.00002508373,0.0002931732,0.0002008307,0.000001426207],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001229741,"about_ca_system_score_gemma":0.00007973098,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001430188,"about_ca_topic_score_gemma":0.0005071583,"domain_scores_codex":[0.9988114,0.0002561166,0.0001376329,0.0002579809,0.0003014439,0.0002354858],"domain_scores_gemma":[0.9992843,0.00003321679,0.00007481215,0.0004375584,0.0001062316,0.00006394029],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.01066632,0.0003915686,0.2014563,0.0002318895,0.0000398089,0.0002140482,0.001042508,9.240914e-7,0.693451,0.00004833948,0.000004321827,0.092453],"study_design_scores_gemma":[0.0008116181,0.01399095,0.9454816,0.00009912786,0.000009019993,0.00008986211,0.0003010425,0.00006668047,0.03796532,0.0001929262,0.000856147,0.0001357079],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978065,0.001343616,0.00001925565,0.0001217396,0.00002069917,0.0003759621,0.00001191875,0.000002586151,0.0002976549],"genre_scores_gemma":[0.9985192,0.00125277,0.00002956804,0.000004771046,0.00005591373,0.00009374564,0.000004060877,0.00001073279,0.00002919749],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.7440253,"threshold_uncertainty_score":0.2930631,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04010243290565214,"score_gpt":0.35423757266045,"score_spread":0.3141351397547979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}