{"id":"W2780912000","doi":"10.1186/s13567-017-0495-5","title":"Detection of PrPBSE and prion infectivity in the ileal Peyer’s patch of young calves as early as 2 months after oral challenge with classical bovine spongiform encephalopathy","year":2017,"lang":"en","type":"article","venue":"Veterinary Research","topic":"Prion Diseases and Protein Misfolding","field":"Biochemistry, Genetics and Molecular Biology","cited_by":10,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail; Canadian Food Inspection Agency","keywords":"Bovine spongiform encephalopathy; Infectivity; Biology; Virology; Bioassay; Immunohistochemistry; Pathogenesis; Genetically modified mouse; Transgene; Prion protein; Immunology; Pathology; Disease; Medicine; Virus; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002144661,0.0002615202,0.0002734238,0.000561005,0.0002235973,0.0004853318,0.000184916,0.0004812188,0.0008083686],"category_scores_gemma":[0.0003334138,0.0002292255,0.0001851276,0.0001993705,0.0002695519,0.000366533,0.0002260849,0.0006093784,0.0003401408],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003289369,"about_ca_system_score_gemma":0.0001448867,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002398899,"about_ca_topic_score_gemma":0.00352644,"domain_scores_codex":[0.9998255,0.00001677652,0.000009822608,0.00004116374,0.00004283908,0.00006398143],"domain_scores_gemma":[0.9996808,0.00004812758,0.0000929303,0.00001174642,0.00006177713,0.0001046791],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003724772,0.00005283908,0.0113822,0.00004901706,0.000009098332,0.0003673644,0.0002348934,0.00001737987,0.9861763,0.00002340578,0.00002281319,0.001292317],"study_design_scores_gemma":[0.00001389666,0.002047821,0.7512095,0.00002778232,0.00006018077,0.001986278,0.0008982473,0.0003577782,0.2418574,0.00007118245,0.001450513,0.00001932941],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977316,0.0007505403,0.0005794673,0.00001427021,0.000007444321,0.00001639771,0.0002204308,0.0000132276,0.0006666823],"genre_scores_gemma":[0.9965514,0.0004965494,0.0005992143,0.00003612389,0.000007183145,0.00002342264,0.0004570661,0.000006314498,0.001822818],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002398899,"threshold_uncertainty_score":0.004769862,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04010243290565214,"score_gpt":0.35423757266045,"score_spread":0.3141351397547979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}