{"id":"W2780991151","doi":"10.1111/imm.12882","title":"Hepatitis C virus core protein reduces <scp>CD</scp>8<sup>+</sup> T‐cell proliferation, perforin production and degranulation but increases <scp>STAT</scp>5 activation","year":2017,"lang":"en","type":"article","venue":"Immunology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Ottawa Public Health; Ottawa Hospital; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; J.P. Bickell Foundation; Canadian Institutes of Health Research; Ontario HIV Treatment Network; Canadian Foundation for AIDS Research","keywords":"Perforin; Biology; Degranulation; Hepatitis C virus; Cytotoxic T cell; T cell; Immunology; Virology; CD8; Molecular biology; Virus; Antigen; Immune system; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006310086,0.0003833432,0.0005529107,0.0004759231,0.001138875,0.0002330962,0.000291141,0.0004244312,0.00004501294],"category_scores_gemma":[0.01152404,0.0003748434,0.00008576379,0.0002351644,0.0006077462,0.0009919675,0.0001947552,0.0006799476,0.0001366245],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002889818,"about_ca_system_score_gemma":0.0004691694,"about_ca_topic_candidate":true,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.008658808,"about_ca_topic_score_gemma":0.0007933161,"domain_scores_codex":[0.9969805,0.0003316018,0.000611461,0.00081867,0.0005754492,0.0006823331],"domain_scores_gemma":[0.9972701,0.0003129583,0.0004740208,0.0009910675,0.0007647844,0.0001870358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001393406,0.0004591445,0.3751411,0.0002512856,0.0001765796,0.00004882044,0.001882781,0.00003476858,0.5903237,0.0001809965,0.002066812,0.02929469],"study_design_scores_gemma":[0.001618867,0.0009305667,0.43202,0.00028845,0.00007969891,0.0001015419,0.0005254431,0.002112794,0.5552346,0.0003370662,0.006650105,0.0001009334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9937822,0.0006209718,0.0001339451,0.0006483085,0.0001945074,0.002643001,0.00005112668,0.0001838159,0.001742177],"genre_scores_gemma":[0.9900184,0.001710061,0.0008537098,0.0000635366,0.0006019566,0.0007119573,0.0003014393,0.00007658555,0.005662359],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05687886,"threshold_uncertainty_score":0.9998704,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0347906830137898,"score_gpt":0.2987992109238368,"score_spread":0.264008527910047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}