{"id":"W2780991151","doi":"10.1111/imm.12882","title":"Hepatitis C virus core protein reduces <scp>CD</scp>8<sup>+</sup> T‐cell proliferation, perforin production and degranulation but increases <scp>STAT</scp>5 activation","year":2017,"lang":"en","type":"article","venue":"Immunology","topic":"Hepatitis C virus research","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University; Ottawa Public Health; Ottawa Hospital; University of Ottawa","funders":"Natural Sciences and Engineering Research Council of Canada; J.P. Bickell Foundation; Canadian Institutes of Health Research; Ontario HIV Treatment Network; Canadian Foundation for AIDS Research","keywords":"Perforin; Biology; Degranulation; Hepatitis C virus; Cytotoxic T cell; T cell; Immunology; Virology; CD8; Molecular biology; Virus; Antigen; Immune system; In vitro","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007912498,0.0002160751,0.0001364136,0.0001169499,0.00005843101,0.0001368146,0.00009664471,0.0001356168,0.002019244],"category_scores_gemma":[0.0001003582,0.00007622951,0.0001527051,0.00007254369,0.0001415866,0.00009028702,0.00009110961,0.0004183562,0.000355525],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000125885,"about_ca_system_score_gemma":0.0001185759,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004519428,"about_ca_topic_score_gemma":0.0006061126,"domain_scores_codex":[0.9999046,0.00002146223,0.0000106833,0.00001255885,0.00002062424,0.00003001742],"domain_scores_gemma":[0.9998864,0.00002637148,0.0000222175,0.0000153901,0.00001335394,0.00003637019],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004898923,0.00004936423,0.000207324,0.00003200419,0.000004937395,0.00001769163,0.000005689815,0.00002942365,0.9983745,0.00001968929,0.00004190371,0.0007276122],"study_design_scores_gemma":[0.00004462442,0.00116792,0.01532851,0.0000069711,0.00002077506,0.0001963494,0.00002391306,0.0005982489,0.981388,0.00002698196,0.001194835,0.000002879429],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.998268,0.0003913331,0.0003689411,0.0000387536,0.00001805945,0.000009946458,0.0001969212,0.0000253106,0.0006826787],"genre_scores_gemma":[0.996812,0.0001962716,0.0004938727,0.00005205702,0.00001079054,0.00002007494,0.0006046001,0.00001055613,0.001799622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002019244,"threshold_uncertainty_score":0.006755114,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0347906830137898,"score_gpt":0.2987992109238368,"score_spread":0.264008527910047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}