{"id":"W2781121917","doi":"10.1177/1740774517746622","title":"TwiC or treat? Are trials within cohorts ethically defensible?","year":2017,"lang":"en","type":"letter","venue":"Clinical Trials","topic":"Ethics in Clinical Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa; Western University","funders":"Canadian Institutes of Health Research; Western University","keywords":"Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaresearch","metaepi_narrow","metaepi_broad","sts","research_integrity","insufficient_payload"],"consensus_categories":["metaresearch","metaepi_narrow","research_integrity","insufficient_payload"],"category_scores_codex":[0.4788214,0.001536704,0.02352841,0.0005798578,0.0005978948,0.000779101,0.002899869,0.03129656,0.005556052],"category_scores_gemma":[0.9713088,0.0009329306,0.008044455,0.0004045771,0.004303422,0.0001502108,0.001121895,0.06485874,0.002928824],"about_ca_system_candidate":true,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003125989,"about_ca_system_score_gemma":0.01144414,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00009970885,"about_ca_topic_score_gemma":0.000263229,"domain_scores_codex":[0.8917019,0.05785098,0.03266924,0.005827654,0.009193896,0.002756352],"domain_scores_gemma":[0.06308647,0.9003653,0.01903599,0.01074376,0.004524124,0.002244374],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.009331556,0.0005434811,0.002859727,0.002140682,0.002470872,0.01531939,0.00003177119,4.539155e-7,0.00002083897,0.0001985028,0.9626213,0.004461459],"study_design_scores_gemma":[0.02013109,0.004063836,0.001803024,0.00923332,0.007123292,0.0002120448,0.00002611161,0.00001213586,0.0001396107,0.05521106,0.900697,0.00134749],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.001157455,0.001122886,0.0000906432,0.9639671,0.01185319,0.007585643,0.000670235,0.0004124487,0.01314034],"genre_scores_gemma":[0.0008774754,0.007850554,0.002543753,0.7249202,0.09810638,0.0004344576,0.0005508272,0.0004411851,0.1642751],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.8425143,"threshold_uncertainty_score":0.9997382,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.9427841256747087,"score_gpt":0.7367492708798408,"score_spread":0.2060348547948679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}