{"id":"W2781121917","doi":"10.1177/1740774517746622","title":"TwiC or treat? Are trials within cohorts ethically defensible?","year":2017,"lang":"en","type":"letter","venue":"Clinical Trials","topic":"Ethics in Clinical Research","field":"Medicine","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"Ottawa Hospital; University of Ottawa; Western University","funders":"Canadian Institutes of Health Research; Western University","keywords":"Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":[],"category_scores_codex":[0.1362307,0.001159557,0.004582498,0.001549597,0.01108014,0.01645336,0.006803303,0.1848912,0.009053907],"category_scores_gemma":[0.3897383,0.002483083,0.002723324,0.002144106,0.03393142,0.01452086,0.008966202,0.1508518,0.006484787],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.01101979,"about_ca_system_score_gemma":0.03073702,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.005996799,"about_ca_topic_score_gemma":0.01398797,"domain_scores_codex":[0.8828398,0.06877846,0.01299645,0.007634128,0.02065256,0.007098631],"domain_scores_gemma":[0.5617151,0.3678548,0.01774702,0.01175989,0.01635744,0.02456566],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"theoretical_or_conceptual","study_design_scores_codex":[0.0002556651,0.0001045698,0.001676732,0.0003419057,0.0002085924,0.001826811,0.001525722,0.0001603244,0.0002450708,0.07516296,0.8948959,0.02359583],"study_design_scores_gemma":[0.000919985,0.0001863966,0.001410058,0.002269077,0.0002536284,0.002152656,0.002147298,0.0008217958,0.0003789676,0.2360574,0.7531686,0.000234205],"study_design_candidate":"theoretical_or_conceptual","study_design_consensus":null,"genre_codex":"commentary","genre_gemma":"commentary","genre_scores_codex":[0.0001394982,0.0007871374,0.0001291475,0.9940791,0.003709,0.00001174947,0.00001212431,0.000005222548,0.001127105],"genre_scores_gemma":[0.001870562,0.000438438,0.0002680546,0.9827315,0.01371641,0.0000575895,0.000008258937,0.00001160931,0.0008976006],"genre_candidate":"commentary","genre_consensus":"commentary","teacher_disagreement_score":0.8637693,"threshold_uncertainty_score":0.7204656,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.9427841256747087,"score_gpt":0.7367492708798408,"score_spread":0.2060348547948679,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}