{"id":"W2781377718","doi":"10.1164/rccm.201709-1840pp","title":"The Low-Risk Profile in Pulmonary Arterial Hypertension. Time for a Paradigm Shift to Goal-oriented Clinical Trial Endpoints?","year":2017,"lang":"en","type":"review","venue":"American Journal of Respiratory and Critical Care Medicine","topic":"Pulmonary Hypertension Research and Treatments","field":"Medicine","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"","keywords":"Medicine; Intensive care medicine; Clinical trial; Paradigm shift; Pulmonary hypertension; Surrogate endpoint; Cardiology; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0109584,0.0005309681,0.004591006,0.0006493092,0.0003345257,0.002879539,0.00155674,0.002497841,0.004233022],"category_scores_gemma":[0.01652092,0.0002734134,0.001711885,0.001043149,0.000950677,0.003148852,0.000895047,0.006649432,0.0009540984],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009152789,"about_ca_system_score_gemma":0.002917712,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006750183,"about_ca_topic_score_gemma":0.00183356,"domain_scores_codex":[0.9973744,0.001339574,0.000386292,0.000275817,0.000505603,0.0001183524],"domain_scores_gemma":[0.9863538,0.01014284,0.00163927,0.0001984615,0.001294915,0.0003706982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001303395,0.0001225363,0.000957027,0.04583867,0.001082084,0.0001174556,0.0001445159,0.0002937856,0.0006877383,0.01228058,0.03777104,0.8994011],"study_design_scores_gemma":[0.002623825,0.001629225,0.01190624,0.1494253,0.005049114,0.001858579,0.0005744906,0.0008025441,0.0005946857,0.04381745,0.7815514,0.000167138],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002513077,0.9901169,0.0001993452,0.008046553,0.0005861701,0.00001410014,0.00003824633,0.000006555599,0.000740887],"genre_scores_gemma":[0.00637986,0.9802766,0.0006299979,0.0090212,0.00323927,0.00007167,0.00006811878,0.000006265466,0.0003070344],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0109584,"threshold_uncertainty_score":0.05795425,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0932809494087312,"score_gpt":0.4378293939044399,"score_spread":0.3445484444957087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}